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An efficacy trial of doxycycline chemoprophylaxis against leptospirosis.
N Engl J Med. 1984 Feb 23; 310(8):497-500.NEJM

Abstract

Because leptospirosis has been an important cause of morbidity in U.S. soldiers training in the Republic of Panama, we conducted a randomized, double-blind, placebo-controlled field trial during the fall of 1982 to determine whether doxycycline was an effective chemoprophylactic agent against this infection. Doxycycline (200 mg) or placebo was administered orally on a weekly basis and at the completion of training to 940 volunteers from two U.S. Army units deployed in Panama for approximately three weeks of jungle training. Twenty cases of leptospirosis occurred in the placebo group (an attack rate of 4.2 per cent), as compared with only one case in the doxycycline group (attack rate, 0.2 per cent, P less than 0.001), yielding an efficacy of 95.0 per cent. This study demonstrated the value of doxycycline as a prophylactic drug against leptospirosis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6363930

Citation

Takafuji, E T., et al. "An Efficacy Trial of Doxycycline Chemoprophylaxis Against Leptospirosis." The New England Journal of Medicine, vol. 310, no. 8, 1984, pp. 497-500.
Takafuji ET, Kirkpatrick JW, Miller RN, et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. N Engl J Med. 1984;310(8):497-500.
Takafuji, E. T., Kirkpatrick, J. W., Miller, R. N., Karwacki, J. J., Kelley, P. W., Gray, M. R., McNeill, K. M., Timboe, H. L., Kane, R. E., & Sanchez, J. L. (1984). An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. The New England Journal of Medicine, 310(8), 497-500.
Takafuji ET, et al. An Efficacy Trial of Doxycycline Chemoprophylaxis Against Leptospirosis. N Engl J Med. 1984 Feb 23;310(8):497-500. PubMed PMID: 6363930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. AU - Takafuji,E T, AU - Kirkpatrick,J W, AU - Miller,R N, AU - Karwacki,J J, AU - Kelley,P W, AU - Gray,M R, AU - McNeill,K M, AU - Timboe,H L, AU - Kane,R E, AU - Sanchez,J L, PY - 1984/2/23/pubmed PY - 1984/2/23/medline PY - 1984/2/23/entrez SP - 497 EP - 500 JF - The New England journal of medicine JO - N Engl J Med VL - 310 IS - 8 N2 - Because leptospirosis has been an important cause of morbidity in U.S. soldiers training in the Republic of Panama, we conducted a randomized, double-blind, placebo-controlled field trial during the fall of 1982 to determine whether doxycycline was an effective chemoprophylactic agent against this infection. Doxycycline (200 mg) or placebo was administered orally on a weekly basis and at the completion of training to 940 volunteers from two U.S. Army units deployed in Panama for approximately three weeks of jungle training. Twenty cases of leptospirosis occurred in the placebo group (an attack rate of 4.2 per cent), as compared with only one case in the doxycycline group (attack rate, 0.2 per cent, P less than 0.001), yielding an efficacy of 95.0 per cent. This study demonstrated the value of doxycycline as a prophylactic drug against leptospirosis. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6363930/An_efficacy_trial_of_doxycycline_chemoprophylaxis_against_leptospirosis_ L2 - https://www.nejm.org/doi/10.1056/NEJM198402233100805?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -