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Gastric lesion and pernicious anemia: a family study.
Acta Hepatogastroenterol (Stuttg). 1978 Feb; 25(1):62-7.AH

Abstract

34 subjects including 5 probands with pernicious anemia, 3 probands with severe atriphic body gastritis and 26 of their first-degree relatives were studied gastroscopically, bioptically, functionally and immunologically. In general, members of the same family revealed a trend to behave similarly with respect to the parameters studied. Signs of A-gastritis (severe atrophy of gastric body glands with a normal or almost normal antrum, achlorhydria, hypergastrinemia and parietal cell antibodies), with intrinsic factor antibodies in the gastric juice and diminished intrinsic factor secretion without anemia were found both in families of probands with atrophic gastritis and pernicious anemia. This suggests a close etiopathogenetic relation of this type of mucosal lesion to overt pernicious anemia. Determination of HCl output and serum gastrin level enabled us to distinguish two differently behaving subgroups in the series, one of them with characteristics of overt adult pernicious anemia. Very low intrinsic factor secretion was found almost exclusively in connection with the presence of intrinsic factor antibodies in the gastric juice and always with severe atrophy of gastric body glands.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

636745

Citation

Varis, K, et al. "Gastric Lesion and Pernicious Anemia: a Family Study." Acta Hepato-gastroenterologica, vol. 25, no. 1, 1978, pp. 62-7.
Varis K, Stenman UH, Lehtola J, et al. Gastric lesion and pernicious anemia: a family study. Acta Hepatogastroenterol (Stuttg). 1978;25(1):62-7.
Varis, K., Stenman, U. H., Lehtola, J., & Siurala, M. (1978). Gastric lesion and pernicious anemia: a family study. Acta Hepato-gastroenterologica, 25(1), 62-7.
Varis K, et al. Gastric Lesion and Pernicious Anemia: a Family Study. Acta Hepatogastroenterol (Stuttg). 1978;25(1):62-7. PubMed PMID: 636745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric lesion and pernicious anemia: a family study. AU - Varis,K, AU - Stenman,U H, AU - Lehtola,J, AU - Siurala,M, PY - 1978/2/1/pubmed PY - 1978/2/1/medline PY - 1978/2/1/entrez SP - 62 EP - 7 JF - Acta hepato-gastroenterologica JO - Acta Hepatogastroenterol (Stuttg) VL - 25 IS - 1 N2 - 34 subjects including 5 probands with pernicious anemia, 3 probands with severe atriphic body gastritis and 26 of their first-degree relatives were studied gastroscopically, bioptically, functionally and immunologically. In general, members of the same family revealed a trend to behave similarly with respect to the parameters studied. Signs of A-gastritis (severe atrophy of gastric body glands with a normal or almost normal antrum, achlorhydria, hypergastrinemia and parietal cell antibodies), with intrinsic factor antibodies in the gastric juice and diminished intrinsic factor secretion without anemia were found both in families of probands with atrophic gastritis and pernicious anemia. This suggests a close etiopathogenetic relation of this type of mucosal lesion to overt pernicious anemia. Determination of HCl output and serum gastrin level enabled us to distinguish two differently behaving subgroups in the series, one of them with characteristics of overt adult pernicious anemia. Very low intrinsic factor secretion was found almost exclusively in connection with the presence of intrinsic factor antibodies in the gastric juice and always with severe atrophy of gastric body glands. SN - 0300-970X UR - https://www.unboundmedicine.com/medline/citation/636745/Gastric_lesion_and_pernicious_anemia:_a_family_study_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -