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An alternative route for infecting armadillos with Mycobacterium leprae.
Microbios. 1984; 39(156):83-6.M

Abstract

A nine-banded armadillo was inoculated with Mycobacterium leprae in both hind footpads. The animals were usually inoculated intravenously, or intradermally in the abdominal skin. Profuse multiplication of the bacilli occurred at the injection sites after more than two years. Eventually bacteraemia developed, and large numbers of the organisms were found in skin biopsies and in lymph nodes. There was limited dissemination of the bacteria into the spleen and the liver, and peripheral nerve invasion by the bacilli was also detected. M. leprae remained viable in the liver tissue, kept frozen at -80 degrees C for three years. This experimental system would be useful in testing the effects of certain immunological and chemotherapeutic agents against M. leprae by injecting them directly at the infection site.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6369076

Citation

Prabhakaran, K, et al. "An Alternative Route for Infecting Armadillos With Mycobacterium Leprae." Microbios, vol. 39, no. 156, 1984, pp. 83-6.
Prabhakaran K, Kirchheimer WF, Sanchez R, et al. An alternative route for infecting armadillos with Mycobacterium leprae. Microbios. 1984;39(156):83-6.
Prabhakaran, K., Kirchheimer, W. F., Sanchez, R., & Harris, E. B. (1984). An alternative route for infecting armadillos with Mycobacterium leprae. Microbios, 39(156), 83-6.
Prabhakaran K, et al. An Alternative Route for Infecting Armadillos With Mycobacterium Leprae. Microbios. 1984;39(156):83-6. PubMed PMID: 6369076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An alternative route for infecting armadillos with Mycobacterium leprae. AU - Prabhakaran,K, AU - Kirchheimer,W F, AU - Sanchez,R, AU - Harris,E B, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 83 EP - 6 JF - Microbios JO - Microbios VL - 39 IS - 156 N2 - A nine-banded armadillo was inoculated with Mycobacterium leprae in both hind footpads. The animals were usually inoculated intravenously, or intradermally in the abdominal skin. Profuse multiplication of the bacilli occurred at the injection sites after more than two years. Eventually bacteraemia developed, and large numbers of the organisms were found in skin biopsies and in lymph nodes. There was limited dissemination of the bacteria into the spleen and the liver, and peripheral nerve invasion by the bacilli was also detected. M. leprae remained viable in the liver tissue, kept frozen at -80 degrees C for three years. This experimental system would be useful in testing the effects of certain immunological and chemotherapeutic agents against M. leprae by injecting them directly at the infection site. SN - 0026-2633 UR - https://www.unboundmedicine.com/medline/citation/6369076/An_alternative_route_for_infecting_armadillos_with_Mycobacterium_leprae_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -