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Serum group I pepsinogens after consecutive stimulations with insulin and pentagastrin in unoperated duodenal ulcer patients and in duodenal ulcer patients after proximal gastric vagotomy.
Scand J Gastroenterol. 1984 Jan; 19(1):52-5.SJ

Abstract

Ten unoperated duodenal ulcer (DU) patients and 11 DU patients 1 year after proximal gastric vagotomy (PGV) were examined for gastric acid secretion and for serum group I pepsinogens (PG I) during basal conditions and after consecutive stimulations with insulin and pentagastrin. In unoperated DU patients insulin stimulation caused a significant increase both in gastric acid secretion and in serum PG I. In these patients a consecutive pentagastrin stimulation elicited a significant increase in gastric acid secretion but not in serum PG I. In patients after PGV, insulin stimulation caused a slight but significant increase in gastric acid secretion but not in serum PG I. In these patients a consecutive pentagastrin stimulation caused a significant increase both in gastric acid secretion and in serum PG I. Two of the operated patients had negative and nine had positive responses to the postoperative insulin test. According to this study, in consecutive stimulation with insulin and pentagastrin the effect of pentagastrin on serum PG I is inhibited by preceding insulin stimulation in DU patients. By PGV the effect of insulin on serum PG I is eliminated. and then a subsequent pentagastrin stimulation elicits a significant rise in serum PG I. As a test of the completeness of PGV, the serum PG I response to insulin-induced hypoglycemia seems to be less sensitive than the gastric acid response.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6369521

Citation

Paimela, H, et al. "Serum Group I Pepsinogens After Consecutive Stimulations With Insulin and Pentagastrin in Unoperated Duodenal Ulcer Patients and in Duodenal Ulcer Patients After Proximal Gastric Vagotomy." Scandinavian Journal of Gastroenterology, vol. 19, no. 1, 1984, pp. 52-5.
Paimela H, Lalla M, Räsänen V. Serum group I pepsinogens after consecutive stimulations with insulin and pentagastrin in unoperated duodenal ulcer patients and in duodenal ulcer patients after proximal gastric vagotomy. Scand J Gastroenterol. 1984;19(1):52-5.
Paimela, H., Lalla, M., & Räsänen, V. (1984). Serum group I pepsinogens after consecutive stimulations with insulin and pentagastrin in unoperated duodenal ulcer patients and in duodenal ulcer patients after proximal gastric vagotomy. Scandinavian Journal of Gastroenterology, 19(1), 52-5.
Paimela H, Lalla M, Räsänen V. Serum Group I Pepsinogens After Consecutive Stimulations With Insulin and Pentagastrin in Unoperated Duodenal Ulcer Patients and in Duodenal Ulcer Patients After Proximal Gastric Vagotomy. Scand J Gastroenterol. 1984;19(1):52-5. PubMed PMID: 6369521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum group I pepsinogens after consecutive stimulations with insulin and pentagastrin in unoperated duodenal ulcer patients and in duodenal ulcer patients after proximal gastric vagotomy. AU - Paimela,H, AU - Lalla,M, AU - Räsänen,V, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 52 EP - 5 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 19 IS - 1 N2 - Ten unoperated duodenal ulcer (DU) patients and 11 DU patients 1 year after proximal gastric vagotomy (PGV) were examined for gastric acid secretion and for serum group I pepsinogens (PG I) during basal conditions and after consecutive stimulations with insulin and pentagastrin. In unoperated DU patients insulin stimulation caused a significant increase both in gastric acid secretion and in serum PG I. In these patients a consecutive pentagastrin stimulation elicited a significant increase in gastric acid secretion but not in serum PG I. In patients after PGV, insulin stimulation caused a slight but significant increase in gastric acid secretion but not in serum PG I. In these patients a consecutive pentagastrin stimulation caused a significant increase both in gastric acid secretion and in serum PG I. Two of the operated patients had negative and nine had positive responses to the postoperative insulin test. According to this study, in consecutive stimulation with insulin and pentagastrin the effect of pentagastrin on serum PG I is inhibited by preceding insulin stimulation in DU patients. By PGV the effect of insulin on serum PG I is eliminated. and then a subsequent pentagastrin stimulation elicits a significant rise in serum PG I. As a test of the completeness of PGV, the serum PG I response to insulin-induced hypoglycemia seems to be less sensitive than the gastric acid response. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/6369521/Serum_group_I_pepsinogens_after_consecutive_stimulations_with_insulin_and_pentagastrin_in_unoperated_duodenal_ulcer_patients_and_in_duodenal_ulcer_patients_after_proximal_gastric_vagotomy_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -