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Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up.
Ann Neurol. 1984 Mar; 15(3):240-4.AN

Abstract

A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia. Baclofen significantly decreased the number of painful paroxysms in 7 of the 10 patients. An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25). On long-term follow-up of one to five years (mean, 3.0 years), 18 of the 60 patients (30%) continued pain free while receiving baclofen; 10 (17%) went into remission after 3 to 6 months; 13 (22%) became refractory to baclofen after 1 to 18 months; and 2 (3%) elected operation despite a good response to baclofen. The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6372646

Citation

Fromm, G H., et al. "Baclofen in the Treatment of Trigeminal Neuralgia: Double-blind Study and Long-term Follow-up." Annals of Neurology, vol. 15, no. 3, 1984, pp. 240-4.
Fromm GH, Terrence CF, Chattha AS. Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Ann Neurol. 1984;15(3):240-4.
Fromm, G. H., Terrence, C. F., & Chattha, A. S. (1984). Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Annals of Neurology, 15(3), 240-4.
Fromm GH, Terrence CF, Chattha AS. Baclofen in the Treatment of Trigeminal Neuralgia: Double-blind Study and Long-term Follow-up. Ann Neurol. 1984;15(3):240-4. PubMed PMID: 6372646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. AU - Fromm,G H, AU - Terrence,C F, AU - Chattha,A S, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 240 EP - 4 JF - Annals of neurology JO - Ann. Neurol. VL - 15 IS - 3 N2 - A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia. Baclofen significantly decreased the number of painful paroxysms in 7 of the 10 patients. An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25). On long-term follow-up of one to five years (mean, 3.0 years), 18 of the 60 patients (30%) continued pain free while receiving baclofen; 10 (17%) went into remission after 3 to 6 months; 13 (22%) became refractory to baclofen after 1 to 18 months; and 2 (3%) elected operation despite a good response to baclofen. The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/6372646/Baclofen_in_the_treatment_of_trigeminal_neuralgia:_double_blind_study_and_long_term_follow_up_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1984&volume=15&issue=3&spage=240 DB - PRIME DP - Unbound Medicine ER -