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Metabolic effects of intensified insulin therapy.
Exp Clin Endocrinol. 1984 Apr; 83(2):130-5.EC

Abstract

Intensified insulin therapy is usually carried out either with multiple subcutaneous insulin injections (ICT: intensified conventional therapy) or with continuous subcutaneous insulin infusion (CSII) by minipumps. For two years we have been studying two matched groups of type I diabetic patients, treated with 3 daily insulin injections (ICT) and with CSII (Microjet , Miles), respectively. Blood glucose control, as assessed by integrated mean blood glucose (MBG), was similar in both groups, but a better metabolic stability ('M' index of Schlichtkrull) was evident in the CSII group. From the 24-hour profiles of plasma 'free' IRI and metabolites (glucose, beta-OH-butyrate, lactate, pyruvate, alanine), both the hepatic and peripheral underinsulinization and related metabolic alterations were still evident in both groups of patients. The number of hypoglycaemic episodes, recorded by home blood glucose monitoring, was similar in both groups of patients, while the perception of symptomatic hypoglycaemia seemed to be reduced in the patients treated with CSII.

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Publisher Full Text

Authors

Brunetti P
No affiliation info available
Bueti A
No affiliation info available
Antonella MA
No affiliation info available
Calabrese G
No affiliation info available
Fabietti PG
No affiliation info available
Santeusanio F
No affiliation info available
Massi Benedetti M
No affiliation info available

MeSH

AlanineBlood GlucoseDiabetes Mellitus, Type 1Drug Administration ScheduleFatty Acids, NonesterifiedGlycerolHumansHypoglycemiaInjections, JetInsulinInsulin Infusion SystemsLactatesPyruvatesPyruvic Acid

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6373314

Citation

Brunetti, P, et al. "Metabolic Effects of Intensified Insulin Therapy." Experimental and Clinical Endocrinology, vol. 83, no. 2, 1984, pp. 130-5.
Brunetti P, Bueti A, Antonella MA, et al. Metabolic effects of intensified insulin therapy. Exp Clin Endocrinol. 1984;83(2):130-5.
Brunetti, P., Bueti, A., Antonella, M. A., Calabrese, G., Fabietti, P. G., Santeusanio, F., & Massi Benedetti, M. (1984). Metabolic effects of intensified insulin therapy. Experimental and Clinical Endocrinology, 83(2), 130-5.
Brunetti P, et al. Metabolic Effects of Intensified Insulin Therapy. Exp Clin Endocrinol. 1984;83(2):130-5. PubMed PMID: 6373314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic effects of intensified insulin therapy. AU - Brunetti,P, AU - Bueti,A, AU - Antonella,M A, AU - Calabrese,G, AU - Fabietti,P G, AU - Santeusanio,F, AU - Massi Benedetti,M, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 130 EP - 5 JF - Experimental and clinical endocrinology JO - Exp Clin Endocrinol VL - 83 IS - 2 N2 - Intensified insulin therapy is usually carried out either with multiple subcutaneous insulin injections (ICT: intensified conventional therapy) or with continuous subcutaneous insulin infusion (CSII) by minipumps. For two years we have been studying two matched groups of type I diabetic patients, treated with 3 daily insulin injections (ICT) and with CSII (Microjet , Miles), respectively. Blood glucose control, as assessed by integrated mean blood glucose (MBG), was similar in both groups, but a better metabolic stability ('M' index of Schlichtkrull) was evident in the CSII group. From the 24-hour profiles of plasma 'free' IRI and metabolites (glucose, beta-OH-butyrate, lactate, pyruvate, alanine), both the hepatic and peripheral underinsulinization and related metabolic alterations were still evident in both groups of patients. The number of hypoglycaemic episodes, recorded by home blood glucose monitoring, was similar in both groups of patients, while the perception of symptomatic hypoglycaemia seemed to be reduced in the patients treated with CSII. SN - 0232-7384 UR - https://www.unboundmedicine.com/medline/citation/6373314/Metabolic_effects_of_intensified_insulin_therapy_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1210321 DB - PRIME DP - Unbound Medicine ER -