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Long-term improvement in metabolic control of unstable type I diabetes by s.c. insulin injection patterns based on the dose profiles required by bed-side artificial beta-cell.
Exp Clin Endocrinol. 1984 Apr; 83(2):143-51.EC

Abstract

Twenty unselected unstable type I diabetic inpatients whose blood glucose control was insufficient employing three daily s.c. injections of regular insulin supplemented by intermediate acting insulin were subjected to a 48-hour treatment with the Biostator -GCIIS when both diet and muscular exercise were kept as close as possible to the conditions at home. The s.c. injection regimen was adjusted to the insulin dose pattern required by the artificial beta cell. There was significant metabolic improvement in 16 out of the 20 patients on discharge, in comparison to the pre-Biostator conditions. This improvement was still present when the patients were re-admitted after an average of seven months. It is concluded that in certain cases of unstable type I diabetes mellitus the metabolic re-arrangement based on intercalary days on an extracorporal artificial beta cell might be useful if the control constants are adapted to minimize the insulin requirement by the machine.

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Publisher Full Text

Authors

Bombor H
No affiliation info available
Bruns W
No affiliation info available
Ratzmann KP
No affiliation info available
Jutzi E
No affiliation info available
Albrecht G
No affiliation info available
Michaelis D
No affiliation info available
Fischer U
No affiliation info available

MeSH

AdolescentAdultBlood GlucoseDiabetes Mellitus, Type 1Drug Administration ScheduleFemaleHumansHypoglycemiaInjections, SubcutaneousInsulinInsulin Infusion SystemsMaleMiddle AgedTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6373316

Citation

Bombor, H, et al. "Long-term Improvement in Metabolic Control of Unstable Type I Diabetes By S.c. Insulin Injection Patterns Based On the Dose Profiles Required By Bed-side Artificial Beta-cell." Experimental and Clinical Endocrinology, vol. 83, no. 2, 1984, pp. 143-51.
Bombor H, Bruns W, Ratzmann KP, et al. Long-term improvement in metabolic control of unstable type I diabetes by s.c. insulin injection patterns based on the dose profiles required by bed-side artificial beta-cell. Exp Clin Endocrinol. 1984;83(2):143-51.
Bombor, H., Bruns, W., Ratzmann, K. P., Jutzi, E., Albrecht, G., Michaelis, D., & Fischer, U. (1984). Long-term improvement in metabolic control of unstable type I diabetes by s.c. insulin injection patterns based on the dose profiles required by bed-side artificial beta-cell. Experimental and Clinical Endocrinology, 83(2), 143-51.
Bombor H, et al. Long-term Improvement in Metabolic Control of Unstable Type I Diabetes By S.c. Insulin Injection Patterns Based On the Dose Profiles Required By Bed-side Artificial Beta-cell. Exp Clin Endocrinol. 1984;83(2):143-51. PubMed PMID: 6373316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term improvement in metabolic control of unstable type I diabetes by s.c. insulin injection patterns based on the dose profiles required by bed-side artificial beta-cell. AU - Bombor,H, AU - Bruns,W, AU - Ratzmann,K P, AU - Jutzi,E, AU - Albrecht,G, AU - Michaelis,D, AU - Fischer,U, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 143 EP - 51 JF - Experimental and clinical endocrinology JO - Exp Clin Endocrinol VL - 83 IS - 2 N2 - Twenty unselected unstable type I diabetic inpatients whose blood glucose control was insufficient employing three daily s.c. injections of regular insulin supplemented by intermediate acting insulin were subjected to a 48-hour treatment with the Biostator -GCIIS when both diet and muscular exercise were kept as close as possible to the conditions at home. The s.c. injection regimen was adjusted to the insulin dose pattern required by the artificial beta cell. There was significant metabolic improvement in 16 out of the 20 patients on discharge, in comparison to the pre-Biostator conditions. This improvement was still present when the patients were re-admitted after an average of seven months. It is concluded that in certain cases of unstable type I diabetes mellitus the metabolic re-arrangement based on intercalary days on an extracorporal artificial beta cell might be useful if the control constants are adapted to minimize the insulin requirement by the machine. SN - 0232-7384 UR - https://www.unboundmedicine.com/medline/citation/6373316/Long_term_improvement_in_metabolic_control_of_unstable_type_I_diabetes_by_s_c__insulin_injection_patterns_based_on_the_dose_profiles_required_by_bed_side_artificial_beta_cell_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1210323 DB - PRIME DP - Unbound Medicine ER -