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Comparison of mutagenicities of N-nitrosamines on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 using rat and hamster liver s9.
Gan. 1984 Jan; 75(1):8-16.GAN

Abstract

The mutagenicities of twelve N-nitrosamines were tested on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 in the presence of rat liver S9 or hamster liver S9 by "preincubation" and "pour-plate" assays. The following eleven N-nitrosamines were mutagenic: N-nitroso-N-dimethylamine; N-nitroso-N-diethylamine; N-nitroso-N-di-n-propylamine; N-nitroso-N-di-n-butylamine; N-nitroso-N-methyl-n- amylamine ; N-nitroso-piperidine; N-nitrosomorpholine; N-nitroso-N-methyl-piperazine; N-nitroso-N-methyl-benzylamine; N-nitroso-N-methyl- phenylamine and N-nitroso-N-phenyl-benzylamine. N-Nitroso-N-diphenylamine was not mutagenic. E. coli WP2 uvrA/pKM101 was more sensitive than S. typhimurium TA100 to the mutagenic actions of N-nitroso-dialkyl amines, N-nitroso- aklyl -aryl amines and N-nitroso- diaryl amines, but S. typhimurium TA100 was more sensitive to those of N-nitroso-cyclic amines. Hamster liver S9 was better than rat liver S9 for metabolic activation of N-nitrosamines, and the preincubation step enhanced the mutagenicities of N-nitrosamines.

Authors

Araki A
No affiliation info available
Muramatsu M
No affiliation info available
Matsushima T
No affiliation info available

MeSH

AnimalsBiotransformationCricetinaeEscherichia coliIn Vitro TechniquesLiverMaleMesocricetusMutagenicity TestsMutagensNitrosaminesRatsRats, Inbred StrainsSalmonella typhimurium

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6373472

Citation

Araki, A, et al. "Comparison of Mutagenicities of N-nitrosamines On Salmonella Typhimurium TA100 and Escherichia Coli WP2 uvrA/pKM101 Using Rat and Hamster Liver S9." Gan, vol. 75, no. 1, 1984, pp. 8-16.
Araki A, Muramatsu M, Matsushima T. Comparison of mutagenicities of N-nitrosamines on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 using rat and hamster liver s9. Gan. 1984;75(1):8-16.
Araki, A., Muramatsu, M., & Matsushima, T. (1984). Comparison of mutagenicities of N-nitrosamines on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 using rat and hamster liver s9. Gan, 75(1), 8-16.
Araki A, Muramatsu M, Matsushima T. Comparison of Mutagenicities of N-nitrosamines On Salmonella Typhimurium TA100 and Escherichia Coli WP2 uvrA/pKM101 Using Rat and Hamster Liver S9. Gan. 1984;75(1):8-16. PubMed PMID: 6373472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of mutagenicities of N-nitrosamines on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 using rat and hamster liver s9. AU - Araki,A, AU - Muramatsu,M, AU - Matsushima,T, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 8 EP - 16 JF - Gan JO - Gan VL - 75 IS - 1 N2 - The mutagenicities of twelve N-nitrosamines were tested on Salmonella typhimurium TA100 and Escherichia coli WP2 uvrA/pKM101 in the presence of rat liver S9 or hamster liver S9 by "preincubation" and "pour-plate" assays. The following eleven N-nitrosamines were mutagenic: N-nitroso-N-dimethylamine; N-nitroso-N-diethylamine; N-nitroso-N-di-n-propylamine; N-nitroso-N-di-n-butylamine; N-nitroso-N-methyl-n- amylamine ; N-nitroso-piperidine; N-nitrosomorpholine; N-nitroso-N-methyl-piperazine; N-nitroso-N-methyl-benzylamine; N-nitroso-N-methyl- phenylamine and N-nitroso-N-phenyl-benzylamine. N-Nitroso-N-diphenylamine was not mutagenic. E. coli WP2 uvrA/pKM101 was more sensitive than S. typhimurium TA100 to the mutagenic actions of N-nitroso-dialkyl amines, N-nitroso- aklyl -aryl amines and N-nitroso- diaryl amines, but S. typhimurium TA100 was more sensitive to those of N-nitroso-cyclic amines. Hamster liver S9 was better than rat liver S9 for metabolic activation of N-nitrosamines, and the preincubation step enhanced the mutagenicities of N-nitrosamines. SN - 0016-450X UR - https://www.unboundmedicine.com/medline/citation/6373472/Comparison_of_mutagenicities_of_N_nitrosamines_on_Salmonella_typhimurium_TA100_and_Escherichia_coli_WP2_uvrA/pKM101_using_rat_and_hamster_liver_s9_ DB - PRIME DP - Unbound Medicine ER -