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The treatment of napkin dermatitis: a double-blind comparison of two steroid-antibiotic combinations.
Pharmatherapeutica. 1984; 3(9):613-7.P

Abstract

A double-blind trial was carried out in 62 infants with moderate to severe napkin dermatitis to assess the effectiveness and acceptability of topical treatment with a miconazole/hydrocortisone preparation compared with that of a nystatin/benzalkonium chloride/dimethicone/hydrocortisone preparation. Patients were allocated at random to one or other treatment and the creams were applied to the affected area 3-times daily for 7 days. At the initial visit, a swab was taken for microbiological investigation. Clinical assessments were made of the signs and symptoms of erythema, weeping, tissue maceration and the more general symptom irritability, before and after 7-days' treatment. Parents were asked to note the time taken to significant improvement of their infant's condition and to comment on ease of application and staining properties of the preparation used. Both treatments produced a high and similar overall cure rate (80% and 84%, respectively), with a significant improvement within 48 hours in the majority of cases. Staining of napkins was reported in significantly fewer cases with the miconazole/hydrocortisone cream.

Authors

Bowring AR
No affiliation info available
Mackay D
No affiliation info available
Taylor FR
No affiliation info available

MeSH

Administration, TopicalAnti-Inflammatory AgentsBenzalkonium CompoundsChild, PreschoolClinical Trials as TopicDiaper RashDouble-Blind MethodDrug CombinationsFemaleHumansHydrocortisoneInfantInfant, NewbornMaleMiconazoleNystatinRandom AllocationSiliconesSimethicone

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6374682

Citation

Bowring, A R., et al. "The Treatment of Napkin Dermatitis: a Double-blind Comparison of Two Steroid-antibiotic Combinations." Pharmatherapeutica, vol. 3, no. 9, 1984, pp. 613-7.
Bowring AR, Mackay D, Taylor FR. The treatment of napkin dermatitis: a double-blind comparison of two steroid-antibiotic combinations. Pharmatherapeutica. 1984;3(9):613-7.
Bowring, A. R., Mackay, D., & Taylor, F. R. (1984). The treatment of napkin dermatitis: a double-blind comparison of two steroid-antibiotic combinations. Pharmatherapeutica, 3(9), 613-7.
Bowring AR, Mackay D, Taylor FR. The Treatment of Napkin Dermatitis: a Double-blind Comparison of Two Steroid-antibiotic Combinations. Pharmatherapeutica. 1984;3(9):613-7. PubMed PMID: 6374682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The treatment of napkin dermatitis: a double-blind comparison of two steroid-antibiotic combinations. AU - Bowring,A R, AU - Mackay,D, AU - Taylor,F R, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 613 EP - 7 JF - Pharmatherapeutica JO - Pharmatherapeutica VL - 3 IS - 9 N2 - A double-blind trial was carried out in 62 infants with moderate to severe napkin dermatitis to assess the effectiveness and acceptability of topical treatment with a miconazole/hydrocortisone preparation compared with that of a nystatin/benzalkonium chloride/dimethicone/hydrocortisone preparation. Patients were allocated at random to one or other treatment and the creams were applied to the affected area 3-times daily for 7 days. At the initial visit, a swab was taken for microbiological investigation. Clinical assessments were made of the signs and symptoms of erythema, weeping, tissue maceration and the more general symptom irritability, before and after 7-days' treatment. Parents were asked to note the time taken to significant improvement of their infant's condition and to comment on ease of application and staining properties of the preparation used. Both treatments produced a high and similar overall cure rate (80% and 84%, respectively), with a significant improvement within 48 hours in the majority of cases. Staining of napkins was reported in significantly fewer cases with the miconazole/hydrocortisone cream. SN - 0308-051X UR - https://www.unboundmedicine.com/medline/citation/6374682/The_treatment_of_napkin_dermatitis:_a_double_blind_comparison_of_two_steroid_antibiotic_combinations_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6374682 DB - PRIME DP - Unbound Medicine ER -