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Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae.
J Infect Dis. 1984 Jun; 149(6):870-3.JI

Abstract

The immunoglobulin classes of the antibody response to the species-specific phenolic glycolipid antigen of Mycobacterium leprae have been characterized for serum specimens from 78 patients with leprosy. These patients included the entire clinical spectrum from paucibacillary to multibacillary disease, including polar tuberculoid (TT; 11 patients), borderline tuberculoid (BT; 15), borderline (BB; 17), borderline lepromatous (BL; 13), and lepromatous (LL; 22)--clinical classifications according to Ridley-Jopling criteria. In each patient group, the levels of IgM antibody to phenolic glycolipid were significantly higher than levels of IgG or IgA. Inhibition experiments with purified antigen showed that antibodies to the phenolic glycolipid dominated the human IgM antibody response to the surface of M. leprae.

Authors

Young DB
No affiliation info available
Dissanayake S
No affiliation info available
Miller RA
No affiliation info available
Khanolkar SR
No affiliation info available
Buchanan TM
No affiliation info available

MeSH

Antibodies, BacterialAntigens, BacterialEnzyme-Linked Immunosorbent AssayGlycolipidsHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MLeprosyMycobacterium lepraeSpecies Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6376654

Citation

Young, D B., et al. "Humans Respond Predominantly With IgM Immunoglobulin to the Species-specific Glycolipid of Mycobacterium Leprae." The Journal of Infectious Diseases, vol. 149, no. 6, 1984, pp. 870-3.
Young DB, Dissanayake S, Miller RA, et al. Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae. J Infect Dis. 1984;149(6):870-3.
Young, D. B., Dissanayake, S., Miller, R. A., Khanolkar, S. R., & Buchanan, T. M. (1984). Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae. The Journal of Infectious Diseases, 149(6), 870-3.
Young DB, et al. Humans Respond Predominantly With IgM Immunoglobulin to the Species-specific Glycolipid of Mycobacterium Leprae. J Infect Dis. 1984;149(6):870-3. PubMed PMID: 6376654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae. AU - Young,D B, AU - Dissanayake,S, AU - Miller,R A, AU - Khanolkar,S R, AU - Buchanan,T M, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 870 EP - 3 JF - The Journal of infectious diseases JO - J Infect Dis VL - 149 IS - 6 N2 - The immunoglobulin classes of the antibody response to the species-specific phenolic glycolipid antigen of Mycobacterium leprae have been characterized for serum specimens from 78 patients with leprosy. These patients included the entire clinical spectrum from paucibacillary to multibacillary disease, including polar tuberculoid (TT; 11 patients), borderline tuberculoid (BT; 15), borderline (BB; 17), borderline lepromatous (BL; 13), and lepromatous (LL; 22)--clinical classifications according to Ridley-Jopling criteria. In each patient group, the levels of IgM antibody to phenolic glycolipid were significantly higher than levels of IgG or IgA. Inhibition experiments with purified antigen showed that antibodies to the phenolic glycolipid dominated the human IgM antibody response to the surface of M. leprae. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/6376654/Humans_respond_predominantly_with_IgM_immunoglobulin_to_the_species_specific_glycolipid_of_Mycobacterium_leprae_ DB - PRIME DP - Unbound Medicine ER -