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Pentoxifylline in the treatment of intermittent claudication of the lower limbs.
Angiology. 1984 Jul; 35(7):389-95.A

Abstract

Pentoxifylline, a methyl xanthine analogue was evaluated for treatment of intermittent claudication in a double-blind placebo controlled parallel group study in seven centers in the United States. Tests were performed on 128 cases, including 42 who took pentoxifylline (600 mg by mouth daily, increased stepwise to 1200 mg daily at the end of one month) and 40 who took placebo for 24 weeks. Twenty-five patients on pentoxifylline and 21 on placebo were dropped from the study for reasons unrelated to the drug. Walking ability on a treadmill was increased significantly after 2 weeks and remained so throughout the study in the pentoxifylline vs. the placebo group. Ability to walk until first experiencing intermittent claudication was a more sensitive index than the maximum ability to walk. The drug did not cause changes in blood pressure or in heart rate. Other than mild nausea, there were no significant side effects.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

6380347

Citation

Reich, T, et al. "Pentoxifylline in the Treatment of Intermittent Claudication of the Lower Limbs." Angiology, vol. 35, no. 7, 1984, pp. 389-95.
Reich T, Cutler BC, Lee BY, et al. Pentoxifylline in the treatment of intermittent claudication of the lower limbs. Angiology. 1984;35(7):389-95.
Reich, T., Cutler, B. C., Lee, B. Y., Porter, J. M., Reichle, F. A., Scogin, J. T., & Strandness, D. E. (1984). Pentoxifylline in the treatment of intermittent claudication of the lower limbs. Angiology, 35(7), 389-95.
Reich T, et al. Pentoxifylline in the Treatment of Intermittent Claudication of the Lower Limbs. Angiology. 1984;35(7):389-95. PubMed PMID: 6380347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline in the treatment of intermittent claudication of the lower limbs. AU - Reich,T, AU - Cutler,B C, AU - Lee,B Y, AU - Porter,J M, AU - Reichle,F A, AU - Scogin,J T, AU - Strandness,D E, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 389 EP - 95 JF - Angiology JO - Angiology VL - 35 IS - 7 N2 - Pentoxifylline, a methyl xanthine analogue was evaluated for treatment of intermittent claudication in a double-blind placebo controlled parallel group study in seven centers in the United States. Tests were performed on 128 cases, including 42 who took pentoxifylline (600 mg by mouth daily, increased stepwise to 1200 mg daily at the end of one month) and 40 who took placebo for 24 weeks. Twenty-five patients on pentoxifylline and 21 on placebo were dropped from the study for reasons unrelated to the drug. Walking ability on a treadmill was increased significantly after 2 weeks and remained so throughout the study in the pentoxifylline vs. the placebo group. Ability to walk until first experiencing intermittent claudication was a more sensitive index than the maximum ability to walk. The drug did not cause changes in blood pressure or in heart rate. Other than mild nausea, there were no significant side effects. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/6380347/Pentoxifylline_in_the_treatment_of_intermittent_claudication_of_the_lower_limbs_ L2 - http://journals.sagepub.com/doi/full/10.1177/000331978403500701?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -