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Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs.
Angiology. 1984 Jul; 35(7):459-66.A

Abstract

The effect of a 3 month daily administration of 800 mg pentoxifylline (Trental 400 bds) or placebo was assessed under double blind crossover design in 18 patients (12 males and 6 females) with peripheral occlusive arterial disease in respect of painfree walking distance and various hemorheological and hemostasiological variables, platelet aggregation, serum cholesterol and triglycerides. In first treatment period walking distance significantly increased with pentoxifylline by 46% from baseline 121 +/- 15 m and by 4% with placebo from baseline 134 +/- 18 m. Pentoxifylline administration furthermore yielded significant decrease in whole blood and plasma viscosity and significant increase in erythrocyte deformability. This was paralleled by distinct reduction of fibrinogen, platelet aggregation and euglobulin lysis time, also plethysmographic variables showed positive changes pointing to improvement of limb perfusion. The results of the study suggest that treatment of peripheral occlusive vascular disease by a drug improving blood fluidity through correction of hemorheological and hemostasiological factors turns especially promising and beneficial since the action centers finally on the languishing microcirculation in the ischemic tissue.

Authors

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Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

6380350

Citation

Strano, A, et al. "Double-blind, Crossover Study of the Clinical Efficacy and the Hemorheological Effects of Pentoxifylline in Patients With Occlusive Arterial Disease of the Lower Limbs." Angiology, vol. 35, no. 7, 1984, pp. 459-66.
Strano A, Davi G, Avellone G, et al. Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs. Angiology. 1984;35(7):459-66.
Strano, A., Davi, G., Avellone, G., Novo, S., & Pinto, A. (1984). Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs. Angiology, 35(7), 459-66.
Strano A, et al. Double-blind, Crossover Study of the Clinical Efficacy and the Hemorheological Effects of Pentoxifylline in Patients With Occlusive Arterial Disease of the Lower Limbs. Angiology. 1984;35(7):459-66. PubMed PMID: 6380350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs. AU - Strano,A, AU - Davi,G, AU - Avellone,G, AU - Novo,S, AU - Pinto,A, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 459 EP - 66 JF - Angiology JO - Angiology VL - 35 IS - 7 N2 - The effect of a 3 month daily administration of 800 mg pentoxifylline (Trental 400 bds) or placebo was assessed under double blind crossover design in 18 patients (12 males and 6 females) with peripheral occlusive arterial disease in respect of painfree walking distance and various hemorheological and hemostasiological variables, platelet aggregation, serum cholesterol and triglycerides. In first treatment period walking distance significantly increased with pentoxifylline by 46% from baseline 121 +/- 15 m and by 4% with placebo from baseline 134 +/- 18 m. Pentoxifylline administration furthermore yielded significant decrease in whole blood and plasma viscosity and significant increase in erythrocyte deformability. This was paralleled by distinct reduction of fibrinogen, platelet aggregation and euglobulin lysis time, also plethysmographic variables showed positive changes pointing to improvement of limb perfusion. The results of the study suggest that treatment of peripheral occlusive vascular disease by a drug improving blood fluidity through correction of hemorheological and hemostasiological factors turns especially promising and beneficial since the action centers finally on the languishing microcirculation in the ischemic tissue. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/6380350/Double_blind_crossover_study_of_the_clinical_efficacy_and_the_hemorheological_effects_of_pentoxifylline_in_patients_with_occlusive_arterial_disease_of_the_lower_limbs_ L2 - http://journals.sagepub.com/doi/full/10.1177/000331978403500709?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -