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Factors predicting remission in type I diabetes.
Ann Clin Res. 1984; 16(2):94-7.AC

Abstract

The remission period often following the clinical onset of insulin-dependent (type I) diabetes, is characterized by residual B cell function, reduced insulin requirements, and good metabolic control. Known factors predicting remission include high age at onset, male sex, mild initial metabolic derangement and absence of frank ketoacidosis. It has been possible to increase the frequency of remissions by strict initial control of diabetes with intensive insulin therapy and by immunological manipulation with corticosteroids, cyclosporin A or plasmapheresis. Patients who have experienced a remission show higher plasma C-peptide levels even after the remission period, but there is no conclusive evidence so far about any beneficial effect of therapeutic intervention on residual B cell function beyond the remission period.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6380392

Citation

Pelkonen, R, and A Aro. "Factors Predicting Remission in Type I Diabetes." Annals of Clinical Research, vol. 16, no. 2, 1984, pp. 94-7.
Pelkonen R, Aro A. Factors predicting remission in type I diabetes. Ann Clin Res. 1984;16(2):94-7.
Pelkonen, R., & Aro, A. (1984). Factors predicting remission in type I diabetes. Annals of Clinical Research, 16(2), 94-7.
Pelkonen R, Aro A. Factors Predicting Remission in Type I Diabetes. Ann Clin Res. 1984;16(2):94-7. PubMed PMID: 6380392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors predicting remission in type I diabetes. AU - Pelkonen,R, AU - Aro,A, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 94 EP - 7 JF - Annals of clinical research JO - Ann Clin Res VL - 16 IS - 2 N2 - The remission period often following the clinical onset of insulin-dependent (type I) diabetes, is characterized by residual B cell function, reduced insulin requirements, and good metabolic control. Known factors predicting remission include high age at onset, male sex, mild initial metabolic derangement and absence of frank ketoacidosis. It has been possible to increase the frequency of remissions by strict initial control of diabetes with intensive insulin therapy and by immunological manipulation with corticosteroids, cyclosporin A or plasmapheresis. Patients who have experienced a remission show higher plasma C-peptide levels even after the remission period, but there is no conclusive evidence so far about any beneficial effect of therapeutic intervention on residual B cell function beyond the remission period. SN - 0003-4762 UR - https://www.unboundmedicine.com/medline/citation/6380392/Factors_predicting_remission_in_type_I_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -