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Electrophysiological studies of the sciatic nerves in Mycobacterium leprae foot pad-injected rats.
Int J Lepr Other Mycobact Dis. 1984 Sep; 52(3):365-70.IJ

Abstract

This study tested the possibility of developing an experimental model of neuropathy in female Wistar rats inoculated with Mycobacterium leprae in the foot pad and assessed by repeated electrophysiological methods. M. leprae multiplied in the rats but considerably less than in simultaneously inoculated mice. No acid-fast bacilli were found in nerves. Motor and sensory conduction velocities remained normal at the thigh level of the sciatic nerve. At the leg, they decreased significantly bilaterally for motor conduction and in the inoculated side for sensory conduction at 21 months after inoculation. These results suggest the possibility of developing an experimental model of leprosy neuropathy which might be useful for therapeutic research. Further histopathological studies are needed to assess this paucibacillary model.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6384077

Citation

Sebille, A, et al. "Electrophysiological Studies of the Sciatic Nerves in Mycobacterium Leprae Foot Pad-injected Rats." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 52, no. 3, 1984, pp. 365-70.
Sebille A, Tabti N, Guelpa CC, et al. Electrophysiological studies of the sciatic nerves in Mycobacterium leprae foot pad-injected rats. Int J Lepr Other Mycobact Dis. 1984;52(3):365-70.
Sebille, A., Tabti, N., Guelpa, C. C., & Giroir, A. M. (1984). Electrophysiological studies of the sciatic nerves in Mycobacterium leprae foot pad-injected rats. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 52(3), 365-70.
Sebille A, et al. Electrophysiological Studies of the Sciatic Nerves in Mycobacterium Leprae Foot Pad-injected Rats. Int J Lepr Other Mycobact Dis. 1984;52(3):365-70. PubMed PMID: 6384077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological studies of the sciatic nerves in Mycobacterium leprae foot pad-injected rats. AU - Sebille,A, AU - Tabti,N, AU - Guelpa,C C, AU - Giroir,A M, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 365 EP - 70 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 52 IS - 3 N2 - This study tested the possibility of developing an experimental model of neuropathy in female Wistar rats inoculated with Mycobacterium leprae in the foot pad and assessed by repeated electrophysiological methods. M. leprae multiplied in the rats but considerably less than in simultaneously inoculated mice. No acid-fast bacilli were found in nerves. Motor and sensory conduction velocities remained normal at the thigh level of the sciatic nerve. At the leg, they decreased significantly bilaterally for motor conduction and in the inoculated side for sensory conduction at 21 months after inoculation. These results suggest the possibility of developing an experimental model of leprosy neuropathy which might be useful for therapeutic research. Further histopathological studies are needed to assess this paucibacillary model. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/6384077/Electrophysiological_studies_of_the_sciatic_nerves_in_Mycobacterium_leprae_foot_pad_injected_rats_ DB - PRIME DP - Unbound Medicine ER -