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Hormonal regulation of electrolyte and water transport in the colon.
Klin Wochenschr. 1984 Jun 15; 62(12):555-63.KW

Abstract

The colon participates in water and electrolyte homeostasis by the absorption of sodium (Na) and water as well as by potassium (K) secretion. The primary step of colonic transport is the active Na transport via a transcellular route. Steroidal hormones considerably increase Na absorption by utilizing two mechanisms: (1) passive Na entry into the cells in enhanced by an increased membrane permeability; (2) active transport capacity is increased by a stimulation of ATPase synthesis. Mineralocorticoid versus glucocorticoid actions of steroids have not yet been clearly differentiated; parallel influences are possible. Active chloride (Cl) secretion is found in the colon under certain pathological conditions and is induced by a number of factors, e.g., hormones produced by pancreas tumors. Cellular events involve a rise of intracellular cAMP and calcium (Ca) concentrations, and altered Cl permeabilities. Functional changes of colonic epithelial cells caused by hormones assume a significant role in the etiology of diarrhea, as well as in compensatory processes by which an intestinal loss of electrolytes and water is prevented.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

6384647

Citation

Lückhoff, A, and M Horster. "Hormonal Regulation of Electrolyte and Water Transport in the Colon." Klinische Wochenschrift, vol. 62, no. 12, 1984, pp. 555-63.
Lückhoff A, Horster M. Hormonal regulation of electrolyte and water transport in the colon. Klin Wochenschr. 1984;62(12):555-63.
Lückhoff, A., & Horster, M. (1984). Hormonal regulation of electrolyte and water transport in the colon. Klinische Wochenschrift, 62(12), 555-63.
Lückhoff A, Horster M. Hormonal Regulation of Electrolyte and Water Transport in the Colon. Klin Wochenschr. 1984 Jun 15;62(12):555-63. PubMed PMID: 6384647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal regulation of electrolyte and water transport in the colon. AU - Lückhoff,A, AU - Horster,M, PY - 1984/6/15/pubmed PY - 1984/6/15/medline PY - 1984/6/15/entrez SP - 555 EP - 63 JF - Klinische Wochenschrift JO - Klin. Wochenschr. VL - 62 IS - 12 N2 - The colon participates in water and electrolyte homeostasis by the absorption of sodium (Na) and water as well as by potassium (K) secretion. The primary step of colonic transport is the active Na transport via a transcellular route. Steroidal hormones considerably increase Na absorption by utilizing two mechanisms: (1) passive Na entry into the cells in enhanced by an increased membrane permeability; (2) active transport capacity is increased by a stimulation of ATPase synthesis. Mineralocorticoid versus glucocorticoid actions of steroids have not yet been clearly differentiated; parallel influences are possible. Active chloride (Cl) secretion is found in the colon under certain pathological conditions and is induced by a number of factors, e.g., hormones produced by pancreas tumors. Cellular events involve a rise of intracellular cAMP and calcium (Ca) concentrations, and altered Cl permeabilities. Functional changes of colonic epithelial cells caused by hormones assume a significant role in the etiology of diarrhea, as well as in compensatory processes by which an intestinal loss of electrolytes and water is prevented. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/6384647/Hormonal_regulation_of_electrolyte_and_water_transport_in_the_colon_ L2 - https://medlineplus.gov/steroids.html DB - PRIME DP - Unbound Medicine ER -