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Insulin autoimmunity as a cause of hypoglycemia.
Arch Intern Med 1984; 144(12):2351-4AI

Abstract

"Autoimmune" hypoglycemia is a syndrome consisting of fasting hypoglycemia, hyperinsulinemia, and insulin-binding antibodies in a patient who has never been exposed to exogenous insulin. The stimulus for insulin-antibody formation and the mechanism of the hypoglycemia in this condition remain unknown. Three patients with this rare syndrome had severe hypoglycemia of limited duration. Two had received a drug containing a sulfhydryl group (methimazole and penicillamine) as treatment for an autoimmune disorder (Graves' disease and rheumatoid arthritis, respectively). A third patient who underwent surgery for a suspected insulinoma was found to have pancreatic beta cell hyperplasia. Drugs containing a sulfhydryl group may have a role in the etiology of the syndrome. Additionally, our findings suggest a relationship between circulating insulin antibodies and beta cell hyperplasia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6391403

Citation

Benson, E A., et al. "Insulin Autoimmunity as a Cause of Hypoglycemia." Archives of Internal Medicine, vol. 144, no. 12, 1984, pp. 2351-4.
Benson EA, Ho P, Wang C, et al. Insulin autoimmunity as a cause of hypoglycemia. Arch Intern Med. 1984;144(12):2351-4.
Benson, E. A., Ho, P., Wang, C., Wu, P. C., Fredlund, P. N., & Yueng, R. T. (1984). Insulin autoimmunity as a cause of hypoglycemia. Archives of Internal Medicine, 144(12), pp. 2351-4.
Benson EA, et al. Insulin Autoimmunity as a Cause of Hypoglycemia. Arch Intern Med. 1984;144(12):2351-4. PubMed PMID: 6391403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin autoimmunity as a cause of hypoglycemia. AU - Benson,E A, AU - Ho,P, AU - Wang,C, AU - Wu,P C, AU - Fredlund,P N, AU - Yueng,R T, PY - 1984/12/1/pubmed PY - 1984/12/1/medline PY - 1984/12/1/entrez SP - 2351 EP - 4 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 144 IS - 12 N2 - "Autoimmune" hypoglycemia is a syndrome consisting of fasting hypoglycemia, hyperinsulinemia, and insulin-binding antibodies in a patient who has never been exposed to exogenous insulin. The stimulus for insulin-antibody formation and the mechanism of the hypoglycemia in this condition remain unknown. Three patients with this rare syndrome had severe hypoglycemia of limited duration. Two had received a drug containing a sulfhydryl group (methimazole and penicillamine) as treatment for an autoimmune disorder (Graves' disease and rheumatoid arthritis, respectively). A third patient who underwent surgery for a suspected insulinoma was found to have pancreatic beta cell hyperplasia. Drugs containing a sulfhydryl group may have a role in the etiology of the syndrome. Additionally, our findings suggest a relationship between circulating insulin antibodies and beta cell hyperplasia. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/6391403/Insulin_autoimmunity_as_a_cause_of_hypoglycemia_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/144/pg/2351 DB - PRIME DP - Unbound Medicine ER -