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Effects of diabetic control and biosynthetic human insulin on blood rheology in established diabetics.
Diabetes Res 1984; 1(1):27-30DR

Abstract

Blood rheology (blood viscosity, haematocrit, plasma viscosity, erythrocyte sedimentation and deformability) was measured in 22 diabetics in a study to compare animal insulins with biosynthetic human insulin. All rheological variables were significantly abnormal in the diabetics when compared with matched normal controls, and were not influenced by the type of insulin injected. However, blood rheology was related to diabetic control, as judged by glycosylated haemoglobin levels; when diabetic control was worst (mean glycosylated haemoglobin 11%), blood viscosity was significantly higher and red cell deformability significantly lower than when control was at its best (mean glycosylated haemoglobin 9.5%). A similar correlation between mean red cell deformability and mean glycosylated haemoglobin was found when individual diabetics were compared (r = 0.66; p less than 0.001). The occurrence of abnormal blood viscosity and red cell deformability during periods of poor diabetic control may contribute to the development of diabetic vascular complications.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6397284

Citation

Leiper, J M., et al. "Effects of Diabetic Control and Biosynthetic Human Insulin On Blood Rheology in Established Diabetics." Diabetes Research (Edinburgh, Scotland), vol. 1, no. 1, 1984, pp. 27-30.
Leiper JM, Lowe GD, Anderson J, et al. Effects of diabetic control and biosynthetic human insulin on blood rheology in established diabetics. Diabetes Res. 1984;1(1):27-30.
Leiper, J. M., Lowe, G. D., Anderson, J., Burns, P., Cohen, H. N., Manderson, W. G., ... MacCuish, A. C. (1984). Effects of diabetic control and biosynthetic human insulin on blood rheology in established diabetics. Diabetes Research (Edinburgh, Scotland), 1(1), pp. 27-30.
Leiper JM, et al. Effects of Diabetic Control and Biosynthetic Human Insulin On Blood Rheology in Established Diabetics. Diabetes Res. 1984;1(1):27-30. PubMed PMID: 6397284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of diabetic control and biosynthetic human insulin on blood rheology in established diabetics. AU - Leiper,J M, AU - Lowe,G D, AU - Anderson,J, AU - Burns,P, AU - Cohen,H N, AU - Manderson,W G, AU - Forbes,C D, AU - Barbenel,J C, AU - MacCuish,A C, PY - 1984/5/1/pubmed PY - 1984/5/1/medline PY - 1984/5/1/entrez SP - 27 EP - 30 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res. VL - 1 IS - 1 N2 - Blood rheology (blood viscosity, haematocrit, plasma viscosity, erythrocyte sedimentation and deformability) was measured in 22 diabetics in a study to compare animal insulins with biosynthetic human insulin. All rheological variables were significantly abnormal in the diabetics when compared with matched normal controls, and were not influenced by the type of insulin injected. However, blood rheology was related to diabetic control, as judged by glycosylated haemoglobin levels; when diabetic control was worst (mean glycosylated haemoglobin 11%), blood viscosity was significantly higher and red cell deformability significantly lower than when control was at its best (mean glycosylated haemoglobin 9.5%). A similar correlation between mean red cell deformability and mean glycosylated haemoglobin was found when individual diabetics were compared (r = 0.66; p less than 0.001). The occurrence of abnormal blood viscosity and red cell deformability during periods of poor diabetic control may contribute to the development of diabetic vascular complications. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/6397284/Effects_of_diabetic_control_and_biosynthetic_human_insulin_on_blood_rheology_in_established_diabetics_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -