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A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study).
Acta Physiol Hung. 1984; 64(3-4):379-84.AP

Abstract

The gastric cytoprotective effects of vitamin A, De-Nol and sucralfate were compared with the effectiveness of pirenzepine in healing ulcer in patients with chronic gastric ulcer. A total of 100 patients was randomized into different groups: the patients were treated with antacids, vitamin A (3 X 50.000 IU), De-Nol liquid (4 X 5 ml), sucralfate (4 X 1 g) or pirenzepine (3 X 50 mg). The treatment was continued for 4 weeks. At the beginning, 2 and 4 weeks after starting treatment the patients were subjected to endoscopy and the size of the ulcer was measured planimetrically. The ulcer-healing effect of De-Nol liquid was significantly better than that of the antacids (p less than 0.01). Ulcer size was reduced significantly in all groups (p less than 0.01), however, at the end of the study the gastric ulcers were smallest in the De-Nol treated group (p less than 0.001). The dynamics of ulcer healing in the second week was most favourable in the patients receiving vitamin A (p less than 0.01). The present data point to the cytoprotective effects of De-Nol liquid, vitamin A and sucralfate and to their ability of healing chronic gastric ulcers.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6397969

Citation

Patty, I, et al. "A Comparative Dynamic Study of the Effectiveness of Gastric Cytoprotection By Vitamin A, De-Nol, Sucralfate and Ulcer Healing By Pirenzepine in Patients With Chronic Gastric Ulcer (a Multiclinical and Randomized Study)." Acta Physiologica Hungarica, vol. 64, no. 3-4, 1984, pp. 379-84.
Patty I, Tárnok F, Simon L, et al. A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). Acta Physiol Hung. 1984;64(3-4):379-84.
Patty, I., Tárnok, F., Simon, L., Jávor, T., Deák, G., Benedek, S., Kenéz, P., Nagy, L., & Mózsik, G. (1984). A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). Acta Physiologica Hungarica, 64(3-4), 379-84.
Patty I, et al. A Comparative Dynamic Study of the Effectiveness of Gastric Cytoprotection By Vitamin A, De-Nol, Sucralfate and Ulcer Healing By Pirenzepine in Patients With Chronic Gastric Ulcer (a Multiclinical and Randomized Study). Acta Physiol Hung. 1984;64(3-4):379-84. PubMed PMID: 6397969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). AU - Patty,I, AU - Tárnok,F, AU - Simon,L, AU - Jávor,T, AU - Deák,G, AU - Benedek,S, AU - Kenéz,P, AU - Nagy,L, AU - Mózsik,G, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 379 EP - 84 JF - Acta physiologica Hungarica JO - Acta Physiol Hung VL - 64 IS - 3-4 N2 - The gastric cytoprotective effects of vitamin A, De-Nol and sucralfate were compared with the effectiveness of pirenzepine in healing ulcer in patients with chronic gastric ulcer. A total of 100 patients was randomized into different groups: the patients were treated with antacids, vitamin A (3 X 50.000 IU), De-Nol liquid (4 X 5 ml), sucralfate (4 X 1 g) or pirenzepine (3 X 50 mg). The treatment was continued for 4 weeks. At the beginning, 2 and 4 weeks after starting treatment the patients were subjected to endoscopy and the size of the ulcer was measured planimetrically. The ulcer-healing effect of De-Nol liquid was significantly better than that of the antacids (p less than 0.01). Ulcer size was reduced significantly in all groups (p less than 0.01), however, at the end of the study the gastric ulcers were smallest in the De-Nol treated group (p less than 0.001). The dynamics of ulcer healing in the second week was most favourable in the patients receiving vitamin A (p less than 0.01). The present data point to the cytoprotective effects of De-Nol liquid, vitamin A and sucralfate and to their ability of healing chronic gastric ulcers. SN - 0231-424X UR - https://www.unboundmedicine.com/medline/citation/6397969/A_comparative_dynamic_study_of_the_effectiveness_of_gastric_cytoprotection_by_vitamin_A_De_Nol_sucralfate_and_ulcer_healing_by_pirenzepine_in_patients_with_chronic_gastric_ulcer__a_multiclinical_and_randomized_study__ DB - PRIME DP - Unbound Medicine ER -