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The relationship of parietal cell, gastrin cell, and thyroid autoantibodies to the state of the gastric mucosa in a population sample.
Scand J Gastroenterol. 1984 Nov; 19(8):1075-80.SJ

Abstract

The occurrence of tissue autoantibodies in relationship to fundal and antral gastritis was examined in an Estonian rural population sample, consisting of 227 persons 15 to 69 years of age. The state of the gastric mucosa was verified with multiple biopsy specimens obtained at direct-vision gastroscopy. Isolated fundal gastritis was characterized as the presence of parietal cell (PCA) and/or thyroid antibodies. PCA was seen only in persons with normal antral mucosa. On the other hand, gastrin cell antibodies (GCA) showed no correlation to the extent of antral gastritis, being seen in normal antrum or in superficial or slight atrophic gastritis but not in moderate or severe gastritis. The findings of our present study thus strengthen the view that the occurrence of PCA is mainly limited to isolated fundal gastritis and excludes the occurrence of antral gastritis. On the other hand, an association of GCA and antral gastritis could not be established.

Authors

Uibo R
No affiliation info available
Krohn K
No affiliation info available
Villako K
No affiliation info available
Tammur R
No affiliation info available
Tamm A
No affiliation info available

MeSH

AdolescentAdultAgedAutoantibodiesEstoniaFemaleFluorescent Antibody TechniqueGastric MucosaGastrinsGastritisHumansImmunoenzyme TechniquesMaleMiddle AgedParietal Cells, GastricRural PopulationThyroid Gland

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6398507

Citation

Uibo, R, et al. "The Relationship of Parietal Cell, Gastrin Cell, and Thyroid Autoantibodies to the State of the Gastric Mucosa in a Population Sample." Scandinavian Journal of Gastroenterology, vol. 19, no. 8, 1984, pp. 1075-80.
Uibo R, Krohn K, Villako K, et al. The relationship of parietal cell, gastrin cell, and thyroid autoantibodies to the state of the gastric mucosa in a population sample. Scand J Gastroenterol. 1984;19(8):1075-80.
Uibo, R., Krohn, K., Villako, K., Tammur, R., & Tamm, A. (1984). The relationship of parietal cell, gastrin cell, and thyroid autoantibodies to the state of the gastric mucosa in a population sample. Scandinavian Journal of Gastroenterology, 19(8), 1075-80.
Uibo R, et al. The Relationship of Parietal Cell, Gastrin Cell, and Thyroid Autoantibodies to the State of the Gastric Mucosa in a Population Sample. Scand J Gastroenterol. 1984;19(8):1075-80. PubMed PMID: 6398507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of parietal cell, gastrin cell, and thyroid autoantibodies to the state of the gastric mucosa in a population sample. AU - Uibo,R, AU - Krohn,K, AU - Villako,K, AU - Tammur,R, AU - Tamm,A, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 1075 EP - 80 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 19 IS - 8 N2 - The occurrence of tissue autoantibodies in relationship to fundal and antral gastritis was examined in an Estonian rural population sample, consisting of 227 persons 15 to 69 years of age. The state of the gastric mucosa was verified with multiple biopsy specimens obtained at direct-vision gastroscopy. Isolated fundal gastritis was characterized as the presence of parietal cell (PCA) and/or thyroid antibodies. PCA was seen only in persons with normal antral mucosa. On the other hand, gastrin cell antibodies (GCA) showed no correlation to the extent of antral gastritis, being seen in normal antrum or in superficial or slight atrophic gastritis but not in moderate or severe gastritis. The findings of our present study thus strengthen the view that the occurrence of PCA is mainly limited to isolated fundal gastritis and excludes the occurrence of antral gastritis. On the other hand, an association of GCA and antral gastritis could not be established. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/6398507/The_relationship_of_parietal_cell_gastrin_cell_and_thyroid_autoantibodies_to_the_state_of_the_gastric_mucosa_in_a_population_sample_ DB - PRIME DP - Unbound Medicine ER -