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IgM antibodies against phenolic glycolipid I from Mycobacterium leprae in leprosy sera: relationship to bacterial index and erythema nodosum leprosum.
Acta Leprol. 1984 Oct-Dec; 2(2-4):394-402.AL

Abstract

Serum IgM antibodies against Mycobacterium leprae-derived phenolic glycolipid I (PG) were determined in 121 leprosy patients, in contacts and controls by an enzyme-linked immunosorbent assay technique. Anti-PG IgM levels correlated with disease classification, increasing from the tuberculoid towards the lepromatous pole of the disease spectrum. There was a linear correlation between serum IgM PG-antibody levels and bacillary index (BI), a measure of bacterial load. Elevated anti-PG IgM in bacillary negative patients was usually indicative of active disease, undetected by BI. We conclude that anti-PG IgM levels are valuable for monitoring the degree of disease activity. Serum anti-PG IgM levels were significantly lower in patients with erythema nodosum leprosum (ENL) as compared to those without ENL, suggesting that IgM PG-antibodies are also involved in the pathogenesis of ENL.

Authors

Schwerer B
No affiliation info available
Meeker HC
No affiliation info available
Sersen G
No affiliation info available
Levis WR
No affiliation info available

MeSH

Antibodies, BacterialEnzyme-Linked Immunosorbent AssayErythema NodosumGlycolipidsHumansImmunoglobulin MLeprosyMycobacterium lepraePhenols

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6398598

Citation

Schwerer, B, et al. "IgM Antibodies Against Phenolic Glycolipid I From Mycobacterium Leprae in Leprosy Sera: Relationship to Bacterial Index and Erythema Nodosum Leprosum." Acta Leprologica, vol. 2, no. 2-4, 1984, pp. 394-402.
Schwerer B, Meeker HC, Sersen G, et al. IgM antibodies against phenolic glycolipid I from Mycobacterium leprae in leprosy sera: relationship to bacterial index and erythema nodosum leprosum. Acta Leprol. 1984;2(2-4):394-402.
Schwerer, B., Meeker, H. C., Sersen, G., & Levis, W. R. (1984). IgM antibodies against phenolic glycolipid I from Mycobacterium leprae in leprosy sera: relationship to bacterial index and erythema nodosum leprosum. Acta Leprologica, 2(2-4), 394-402.
Schwerer B, et al. IgM Antibodies Against Phenolic Glycolipid I From Mycobacterium Leprae in Leprosy Sera: Relationship to Bacterial Index and Erythema Nodosum Leprosum. Acta Leprol. 1984 Oct-Dec;2(2-4):394-402. PubMed PMID: 6398598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgM antibodies against phenolic glycolipid I from Mycobacterium leprae in leprosy sera: relationship to bacterial index and erythema nodosum leprosum. AU - Schwerer,B, AU - Meeker,H C, AU - Sersen,G, AU - Levis,W R, PY - 1984/10/1/pubmed PY - 1984/10/1/medline PY - 1984/10/1/entrez SP - 394 EP - 402 JF - Acta leprologica JO - Acta Leprol VL - 2 IS - 2-4 N2 - Serum IgM antibodies against Mycobacterium leprae-derived phenolic glycolipid I (PG) were determined in 121 leprosy patients, in contacts and controls by an enzyme-linked immunosorbent assay technique. Anti-PG IgM levels correlated with disease classification, increasing from the tuberculoid towards the lepromatous pole of the disease spectrum. There was a linear correlation between serum IgM PG-antibody levels and bacillary index (BI), a measure of bacterial load. Elevated anti-PG IgM in bacillary negative patients was usually indicative of active disease, undetected by BI. We conclude that anti-PG IgM levels are valuable for monitoring the degree of disease activity. Serum anti-PG IgM levels were significantly lower in patients with erythema nodosum leprosum (ENL) as compared to those without ENL, suggesting that IgM PG-antibodies are also involved in the pathogenesis of ENL. SN - 0001-5938 UR - https://www.unboundmedicine.com/medline/citation/6398598/IgM_antibodies_against_phenolic_glycolipid_I_from_Mycobacterium_leprae_in_leprosy_sera:_relationship_to_bacterial_index_and_erythema_nodosum_leprosum_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -