Tags

Type your tag names separated by a space and hit enter

Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women.
Am J Obstet Gynecol. 1983 Jan 15; 145(2):152-7.AJ

Abstract

The plasma concentrations of total testosterone, free testosterone index, androstenedione, 17 beta-estradiol, luteinizing hormone, follicle-stimulating hormone, prolactin, and urinary 17-ketosteroid and 17-ketogenic steroid excretion were measured in 48 nonhirsute and 119 hirsute patients. Hormone data were compared within and between groups according to whether the menstrual cycles were eumenorrheic, amenorrheic, or oligomenorrheic. Eleven hirsute women treated with prednisone were followed for 6 months. It was concluded that: (1) androstenedione, testosterone, free testosterone index, and adrenal androgens alone or in combination play a role in the pathogenesis of the hirsutism observed in eumenorrheic women and in the amenorrhea and oligomenorrhea of both hirsute and nonhirsute women; (2) body weight correlated with adrenal adrogens (17-ketosteroids) in nonhirsute women and with androstenedione in hirsute women; (3) prednisone significantly suppressed androstenedione and 17-ketosteroids (p less than 0.05), with a decline of testosterone to 65% and luteinizing hormone to 51% of pretreatment values, with favorable clinical effects on the hirsutism, menstrual dysfunction, and infertility; (4) concentrations of 17 beta-estradiol were lower in amenorrheic than in eumenorrheic and oligomenorrheic women of both groups.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6401396

Citation

Ho Yuen, B, and E K. Mincey. "Role of Androgens in Menstrual Disorders of Nonhirsute and Hirsute Women, and the Effect of Glucocorticoid Therapy On Androgen Levels in Hirsute Hyperandrogenic Women." American Journal of Obstetrics and Gynecology, vol. 145, no. 2, 1983, pp. 152-7.
Ho Yuen B, Mincey EK. Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women. Am J Obstet Gynecol. 1983;145(2):152-7.
Ho Yuen, B., & Mincey, E. K. (1983). Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women. American Journal of Obstetrics and Gynecology, 145(2), 152-7.
Ho Yuen B, Mincey EK. Role of Androgens in Menstrual Disorders of Nonhirsute and Hirsute Women, and the Effect of Glucocorticoid Therapy On Androgen Levels in Hirsute Hyperandrogenic Women. Am J Obstet Gynecol. 1983 Jan 15;145(2):152-7. PubMed PMID: 6401396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women. AU - Ho Yuen,B, AU - Mincey,E K, PY - 1983/1/15/pubmed PY - 1983/1/15/medline PY - 1983/1/15/entrez SP - 152 EP - 7 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 145 IS - 2 N2 - The plasma concentrations of total testosterone, free testosterone index, androstenedione, 17 beta-estradiol, luteinizing hormone, follicle-stimulating hormone, prolactin, and urinary 17-ketosteroid and 17-ketogenic steroid excretion were measured in 48 nonhirsute and 119 hirsute patients. Hormone data were compared within and between groups according to whether the menstrual cycles were eumenorrheic, amenorrheic, or oligomenorrheic. Eleven hirsute women treated with prednisone were followed for 6 months. It was concluded that: (1) androstenedione, testosterone, free testosterone index, and adrenal androgens alone or in combination play a role in the pathogenesis of the hirsutism observed in eumenorrheic women and in the amenorrhea and oligomenorrhea of both hirsute and nonhirsute women; (2) body weight correlated with adrenal adrogens (17-ketosteroids) in nonhirsute women and with androstenedione in hirsute women; (3) prednisone significantly suppressed androstenedione and 17-ketosteroids (p less than 0.05), with a decline of testosterone to 65% and luteinizing hormone to 51% of pretreatment values, with favorable clinical effects on the hirsutism, menstrual dysfunction, and infertility; (4) concentrations of 17 beta-estradiol were lower in amenorrheic than in eumenorrheic and oligomenorrheic women of both groups. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/6401396/Role_of_androgens_in_menstrual_disorders_of_nonhirsute_and_hirsute_women_and_the_effect_of_glucocorticoid_therapy_on_androgen_levels_in_hirsute_hyperandrogenic_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(83)90482-9 DB - PRIME DP - Unbound Medicine ER -