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24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics.
Diabetes. 1978 Mar; 27(3):300-6.D

Abstract

Somatostatin was infused in various doses into normal subjects and juvenile diabetics for a 24-hour period preceded by a 24-hour control period and followed by another three-hour control period. Saline was infused during the first control period. Meals were served during the two 24-hour periods. Blood samples were taken hourly. Five normal males received a total dose of 4 mg. somatostatin. Four male diabetics received 2 mg., four received 4 mg., and four 6 mg. In the diabetics, somatostatin suppressed plasma growth hormone, glucagon, and glucose throughout the infusion. All parameters rebounded at cessation of infusion. In the normals, somatostatin suppressed plasma growth hormone, glucagon, and insulin but increased plasma glucose. It is concluded that the plasma glucose suppression in the diabetics is mainly due to the suppression of the diabetogenic hormones growth hormone and glucagon. A minor effect of decreased and/or delayed absorption of carbohydrates cannot be excluded in these experiments. The elevated plasma glucose levels in normals must be due to the suppressive effects of somatostatin on insulin secretion.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

640235

Citation

Christensen, S E., et al. "24-hour Studies of the Effects of Somatostatin On the Levels of Plasma Growth Hormone, Glucagon, and Glucose in Normal Subjects and Juvenile Diabetics." Diabetes, vol. 27, no. 3, 1978, pp. 300-6.
Christensen SE, Hansen AP, Weeke J, et al. 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics. Diabetes. 1978;27(3):300-6.
Christensen, S. E., Hansen, A. P., Weeke, J., & Lundbaek, K. (1978). 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics. Diabetes, 27(3), 300-6.
Christensen SE, et al. 24-hour Studies of the Effects of Somatostatin On the Levels of Plasma Growth Hormone, Glucagon, and Glucose in Normal Subjects and Juvenile Diabetics. Diabetes. 1978;27(3):300-6. PubMed PMID: 640235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics. AU - Christensen,S E, AU - Hansen,A P, AU - Weeke,J, AU - Lundbaek,K, PY - 1978/3/1/pubmed PY - 1978/3/1/medline PY - 1978/3/1/entrez SP - 300 EP - 6 JF - Diabetes JO - Diabetes VL - 27 IS - 3 N2 - Somatostatin was infused in various doses into normal subjects and juvenile diabetics for a 24-hour period preceded by a 24-hour control period and followed by another three-hour control period. Saline was infused during the first control period. Meals were served during the two 24-hour periods. Blood samples were taken hourly. Five normal males received a total dose of 4 mg. somatostatin. Four male diabetics received 2 mg., four received 4 mg., and four 6 mg. In the diabetics, somatostatin suppressed plasma growth hormone, glucagon, and glucose throughout the infusion. All parameters rebounded at cessation of infusion. In the normals, somatostatin suppressed plasma growth hormone, glucagon, and insulin but increased plasma glucose. It is concluded that the plasma glucose suppression in the diabetics is mainly due to the suppression of the diabetogenic hormones growth hormone and glucagon. A minor effect of decreased and/or delayed absorption of carbohydrates cannot be excluded in these experiments. The elevated plasma glucose levels in normals must be due to the suppressive effects of somatostatin on insulin secretion. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/640235/24_hour_studies_of_the_effects_of_somatostatin_on_the_levels_of_plasma_growth_hormone_glucagon_and_glucose_in_normal_subjects_and_juvenile_diabetics_ L2 - https://diabetesjournals.org/diabetes/article-lookup/doi/10.2337/diab.27.3.300 DB - PRIME DP - Unbound Medicine ER -