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Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus.
J Clin Endocrinol Metab. 1983 May; 56(5):1016-21.JC

Abstract

Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus. Nine normal menstruating diabetic women, 12 normal women in the early follicular phase, and nine consecutive nondiabetic women with functional amenorrhea served as controls. No significant differences were found in relation to diabetes regulation within the two diabetic groups. Amenorrheic patients with diabetes mellitus had significantly lower basal PRL levels than normal women and estradiol levels compared to the other groups. Basal plasma LH concentrations were significantly lower in women with amenorrhea and diabetes mellitus than in nondiabetics with amenorrhea, whereas plasma FSH levels were similar in all groups. The LH response to GnRH was significantly lower in amenorrheic patients with diabetes mellitus than in normal women, and a significant correlation (r = 0.81, P less than 0.01) was found between the LH response to GnRH and the basal estradiol level in these women. The FSH response to GnRH and the PRL response to TRH were similar in all groups. Amenorrheic diabetics had significantly lower PRL responses to MTC compared to other groups, and nondiabetics with amenorrhea had significantly lower PRL response than normal women. It is concluded that diabetic patients with functional amenorrhea have low basal and MTC-stimulated PRL levels, low basal LH levels, and decreased LH response to GnRH despite low estrogen levels. These hormonal changes may in part be caused by a raised central dopaminergic activity leading to a depression of pituitary ovulatory mechanisms.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6403566

Citation

Djursing, H, et al. "Gonadotropin Responses to Gonadotropin-releasing Hormone and Prolactin Responses to Thyrotropin-releasing Hormone and Metoclopramide in Women With Amenorrhea and Insulin-treated Diabetes Mellitus." The Journal of Clinical Endocrinology and Metabolism, vol. 56, no. 5, 1983, pp. 1016-21.
Djursing H, Hagen C, Nyholm HC, et al. Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. J Clin Endocrinol Metab. 1983;56(5):1016-21.
Djursing, H., Hagen, C., Nyholm, H. C., Carstensen, L., & Andersen, A. N. (1983). Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism, 56(5), 1016-21.
Djursing H, et al. Gonadotropin Responses to Gonadotropin-releasing Hormone and Prolactin Responses to Thyrotropin-releasing Hormone and Metoclopramide in Women With Amenorrhea and Insulin-treated Diabetes Mellitus. J Clin Endocrinol Metab. 1983;56(5):1016-21. PubMed PMID: 6403566.
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TY - JOUR T1 - Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. AU - Djursing,H, AU - Hagen,C, AU - Nyholm,H C, AU - Carstensen,L, AU - Andersen,A N, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 1016 EP - 21 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 56 IS - 5 N2 - Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus. Nine normal menstruating diabetic women, 12 normal women in the early follicular phase, and nine consecutive nondiabetic women with functional amenorrhea served as controls. No significant differences were found in relation to diabetes regulation within the two diabetic groups. Amenorrheic patients with diabetes mellitus had significantly lower basal PRL levels than normal women and estradiol levels compared to the other groups. Basal plasma LH concentrations were significantly lower in women with amenorrhea and diabetes mellitus than in nondiabetics with amenorrhea, whereas plasma FSH levels were similar in all groups. The LH response to GnRH was significantly lower in amenorrheic patients with diabetes mellitus than in normal women, and a significant correlation (r = 0.81, P less than 0.01) was found between the LH response to GnRH and the basal estradiol level in these women. The FSH response to GnRH and the PRL response to TRH were similar in all groups. Amenorrheic diabetics had significantly lower PRL responses to MTC compared to other groups, and nondiabetics with amenorrhea had significantly lower PRL response than normal women. It is concluded that diabetic patients with functional amenorrhea have low basal and MTC-stimulated PRL levels, low basal LH levels, and decreased LH response to GnRH despite low estrogen levels. These hormonal changes may in part be caused by a raised central dopaminergic activity leading to a depression of pituitary ovulatory mechanisms. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6403566/Gonadotropin_responses_to_gonadotropin_releasing_hormone_and_prolactin_responses_to_thyrotropin_releasing_hormone_and_metoclopramide_in_women_with_amenorrhea_and_insulin_treated_diabetes_mellitus_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-56-5-1016 DB - PRIME DP - Unbound Medicine ER -