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Pigeon breeder's lung: association with HLA-DR 3.
Tissue Antigens. 1983 May; 21(5):374-9.TA

Abstract

52 symptomatic (SPB) and 64 asymptomatic (APB) pigeon breeders were investigated for the HLA-A, -B, -C, -DR; C2, C3, C4 and Bf systems, and C3, C4 and factor B serum concentrations. HLA-DR3 and Bf S frequencies were significantly higher in the SPB than the APB group. Mean factor B concentrations were lower in the SPB than in the APB group. A positive two-way association between HLA-DR3 and the disease was found. It is concluded that a gene or genes responsible for type III and IV allergic reactions leading to the disease is associated with HLA-DR3. The increase of Bf S allotype and low mean factor B concentrations, however, can be explained by the strong linkage disequilibrium between BfS and HLA-DR3.

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Publisher Full Text

Authors

Rittner C
No affiliation info available
Sennekamp J
No affiliation info available
Mollenhauer E
No affiliation info available
Rösinger N
No affiliation info available
Niese D
No affiliation info available
Lüttkenhorst M
No affiliation info available
Baur MP
No affiliation info available
Stroehmann I
No affiliation info available

MeSH

Alveolitis, Extrinsic AllergicBird Fancier's LungComplement C3Complement C4Gene FrequencyGenes, MHC Class IIHLA AntigensHumans

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6408759

Citation

Rittner, C, et al. "Pigeon Breeder's Lung: Association With HLA-DR 3." Tissue Antigens, vol. 21, no. 5, 1983, pp. 374-9.
Rittner C, Sennekamp J, Mollenhauer E, et al. Pigeon breeder's lung: association with HLA-DR 3. Tissue Antigens. 1983;21(5):374-9.
Rittner, C., Sennekamp, J., Mollenhauer, E., Rösinger, N., Niese, D., Lüttkenhorst, M., Baur, M. P., & Stroehmann, I. (1983). Pigeon breeder's lung: association with HLA-DR 3. Tissue Antigens, 21(5), 374-9.
Rittner C, et al. Pigeon Breeder's Lung: Association With HLA-DR 3. Tissue Antigens. 1983;21(5):374-9. PubMed PMID: 6408759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pigeon breeder's lung: association with HLA-DR 3. AU - Rittner,C, AU - Sennekamp,J, AU - Mollenhauer,E, AU - Rösinger,N, AU - Niese,D, AU - Lüttkenhorst,M, AU - Baur,M P, AU - Stroehmann,I, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 374 EP - 9 JF - Tissue antigens JO - Tissue Antigens VL - 21 IS - 5 N2 - 52 symptomatic (SPB) and 64 asymptomatic (APB) pigeon breeders were investigated for the HLA-A, -B, -C, -DR; C2, C3, C4 and Bf systems, and C3, C4 and factor B serum concentrations. HLA-DR3 and Bf S frequencies were significantly higher in the SPB than the APB group. Mean factor B concentrations were lower in the SPB than in the APB group. A positive two-way association between HLA-DR3 and the disease was found. It is concluded that a gene or genes responsible for type III and IV allergic reactions leading to the disease is associated with HLA-DR3. The increase of Bf S allotype and low mean factor B concentrations, however, can be explained by the strong linkage disequilibrium between BfS and HLA-DR3. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/6408759/Pigeon_breeder's_lung:_association_with_HLA_DR_3_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=1983&volume=21&issue=5&spage=374 DB - PRIME DP - Unbound Medicine ER -