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Single daily dose short term carbimazole therapy for hyperthyroid Graves' disease.
Clin Endocrinol (Oxf). 1983 Jun; 18(6):557-61.CE

Abstract

Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alkaline phosphatase concentrations took longer to respond. In 19 patients a positive thyroid stimulating hormone (TSH) response to intravenous thyrotrophin releasing hormone (TRH) developed. Carbimazole was stopped soon after (median time of treatment 18 weeks, range 9-41 weeks) and 18 patients have been followed. Seven of these (39%) have remained in remission from hyperthyroidism for more than one year (median 77 weeks). Carbimazole 30 mg once daily is a convenient and effective treatment for hyperthyroid Graves' disease. Many patients will achieve prolonged remissions if treatment is stopped when serum T3 and T4 levels are in the low-normal range, usually 2-4 months after clinical euthyroidism has been reached.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6411390

Citation

MacFarlane, I A., et al. "Single Daily Dose Short Term Carbimazole Therapy for Hyperthyroid Graves' Disease." Clinical Endocrinology, vol. 18, no. 6, 1983, pp. 557-61.
MacFarlane IA, Davies D, Longson D, et al. Single daily dose short term carbimazole therapy for hyperthyroid Graves' disease. Clin Endocrinol (Oxf). 1983;18(6):557-61.
MacFarlane, I. A., Davies, D., Longson, D., Shalet, S. M., & Beardwell, C. G. (1983). Single daily dose short term carbimazole therapy for hyperthyroid Graves' disease. Clinical Endocrinology, 18(6), 557-61.
MacFarlane IA, et al. Single Daily Dose Short Term Carbimazole Therapy for Hyperthyroid Graves' Disease. Clin Endocrinol (Oxf). 1983;18(6):557-61. PubMed PMID: 6411390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single daily dose short term carbimazole therapy for hyperthyroid Graves' disease. AU - MacFarlane,I A, AU - Davies,D, AU - Longson,D, AU - Shalet,S M, AU - Beardwell,C G, PY - 1983/6/1/pubmed PY - 1983/6/1/medline PY - 1983/6/1/entrez SP - 557 EP - 61 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 18 IS - 6 N2 - Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alkaline phosphatase concentrations took longer to respond. In 19 patients a positive thyroid stimulating hormone (TSH) response to intravenous thyrotrophin releasing hormone (TRH) developed. Carbimazole was stopped soon after (median time of treatment 18 weeks, range 9-41 weeks) and 18 patients have been followed. Seven of these (39%) have remained in remission from hyperthyroidism for more than one year (median 77 weeks). Carbimazole 30 mg once daily is a convenient and effective treatment for hyperthyroid Graves' disease. Many patients will achieve prolonged remissions if treatment is stopped when serum T3 and T4 levels are in the low-normal range, usually 2-4 months after clinical euthyroidism has been reached. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/6411390/Single_daily_dose_short_term_carbimazole_therapy_for_hyperthyroid_Graves'_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1983&volume=18&issue=6&spage=557 DB - PRIME DP - Unbound Medicine ER -