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Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.
Am J Psychiatry. 1983 Sep; 140(9):1145-9.AJ

Abstract

Chronic alcoholics who had been abstinent from alcohol for more than 2 years were evaluated with the thyrotropin-releasing hormone (TRH) test. The findings suggest the following profound disturbances in the hypothalamic-pituitary-thyroid axis: 1) a "euthyroid sick syndrome," evidenced by low levels of triiodothyronine (T3), high levels of reverse T3, and normal levels of thyroxine (T4) (this syndrome implies a decreased 5'-deiodination of T4 to T3 and of reverse T3 to its lesser iodinated metabolites), 2) an increased binding capacity for thyroid hormones, evidenced by a decreased T3-uptake value and an increased level of T4-binding globulin, and 3) thyroid-stimulating hormone (TSH) blunting in 31% of patients. Paradoxically, there was a positive correlation between basal T4 and delta max TSH in subjects with blunted TSH, but baseline TSH levels were reduced in subjects with and without blunted TSH.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6412572

Citation

Loosen, P T., et al. "Thyrotropin-releasing Hormone (TRH) in Abstinent Alcoholic Men." The American Journal of Psychiatry, vol. 140, no. 9, 1983, pp. 1145-9.
Loosen PT, Wilson IC, Dew BW, et al. Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men. Am J Psychiatry. 1983;140(9):1145-9.
Loosen, P. T., Wilson, I. C., Dew, B. W., & Tipermas, A. (1983). Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men. The American Journal of Psychiatry, 140(9), 1145-9.
Loosen PT, et al. Thyrotropin-releasing Hormone (TRH) in Abstinent Alcoholic Men. Am J Psychiatry. 1983;140(9):1145-9. PubMed PMID: 6412572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men. AU - Loosen,P T, AU - Wilson,I C, AU - Dew,B W, AU - Tipermas,A, PY - 1983/9/1/pubmed PY - 1983/9/1/medline PY - 1983/9/1/entrez SP - 1145 EP - 9 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 140 IS - 9 N2 - Chronic alcoholics who had been abstinent from alcohol for more than 2 years were evaluated with the thyrotropin-releasing hormone (TRH) test. The findings suggest the following profound disturbances in the hypothalamic-pituitary-thyroid axis: 1) a "euthyroid sick syndrome," evidenced by low levels of triiodothyronine (T3), high levels of reverse T3, and normal levels of thyroxine (T4) (this syndrome implies a decreased 5'-deiodination of T4 to T3 and of reverse T3 to its lesser iodinated metabolites), 2) an increased binding capacity for thyroid hormones, evidenced by a decreased T3-uptake value and an increased level of T4-binding globulin, and 3) thyroid-stimulating hormone (TSH) blunting in 31% of patients. Paradoxically, there was a positive correlation between basal T4 and delta max TSH in subjects with blunted TSH, but baseline TSH levels were reduced in subjects with and without blunted TSH. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/6412572/Thyrotropin_releasing_hormone__TRH__in_abstinent_alcoholic_men_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.140.9.1145?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -