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Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility.
J Biomed Mater Res. 1983 Sep; 17(5):865-71.JB

Abstract

A histological evaluation of the biocompatibility of a new porous hydrogel membrane made of 2-hydroxyethyl methacrylate (2-HEMA) was performed. Isolated membranes and diffusion chambers made of this material and filled with rabbit pancreas were implanted in diabetic rats for periods of up to 8 1/2 months. Histologic evaluation showed that this polymer elicits minimal tissue reaction within the first 7 weeks but some increase in granulation tissue and fibrosis thereafter. A component of this tissue reaction is neovascularization, and many blood vessels were noted immediately adjacent to the membrane's surface. Calcification of the membrane was also progressive but could be minimized by formulations resulting in the incorporation of acid groups throughout the hydrogel and on its surface. Diffusion chambers made of this new material show promise for use in a "hybrid" artificial pancreas for the treatment of diabetes.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6413510

Citation

Klomp, G F., et al. "Macroporous Hydrogel Membranes for a Hybrid Artificial Pancreas. II. Biocompatibility." Journal of Biomedical Materials Research, vol. 17, no. 5, 1983, pp. 865-71.
Klomp GF, Hashiguchi H, Ursell PC, et al. Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility. J Biomed Mater Res. 1983;17(5):865-71.
Klomp, G. F., Hashiguchi, H., Ursell, P. C., Takeda, Y., Taguchi, T., & Dobelle, W. H. (1983). Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility. Journal of Biomedical Materials Research, 17(5), 865-71.
Klomp GF, et al. Macroporous Hydrogel Membranes for a Hybrid Artificial Pancreas. II. Biocompatibility. J Biomed Mater Res. 1983;17(5):865-71. PubMed PMID: 6413510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility. AU - Klomp,G F, AU - Hashiguchi,H, AU - Ursell,P C, AU - Takeda,Y, AU - Taguchi,T, AU - Dobelle,W H, PY - 1983/9/1/pubmed PY - 1983/9/1/medline PY - 1983/9/1/entrez SP - 865 EP - 71 JF - Journal of biomedical materials research JO - J Biomed Mater Res VL - 17 IS - 5 N2 - A histological evaluation of the biocompatibility of a new porous hydrogel membrane made of 2-hydroxyethyl methacrylate (2-HEMA) was performed. Isolated membranes and diffusion chambers made of this material and filled with rabbit pancreas were implanted in diabetic rats for periods of up to 8 1/2 months. Histologic evaluation showed that this polymer elicits minimal tissue reaction within the first 7 weeks but some increase in granulation tissue and fibrosis thereafter. A component of this tissue reaction is neovascularization, and many blood vessels were noted immediately adjacent to the membrane's surface. Calcification of the membrane was also progressive but could be minimized by formulations resulting in the incorporation of acid groups throughout the hydrogel and on its surface. Diffusion chambers made of this new material show promise for use in a "hybrid" artificial pancreas for the treatment of diabetes. SN - 0021-9304 UR - https://www.unboundmedicine.com/medline/citation/6413510/Macroporous_hydrogel_membranes_for_a_hybrid_artificial_pancreas__II__Biocompatibility_ L2 - https://doi.org/10.1002/jbm.820170513 DB - PRIME DP - Unbound Medicine ER -