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Linoleic acid effects on epidermal DNA synthesis and cutaneous prostaglandin levels in essential fatty acid deficiency.
J Invest Dermatol. 1978 Apr; 70(4):200-3.JI

Abstract

An essential fatty acid (EFA) deficient state has been induced in hairless mice. The epidermal changes included hyperkeratosis, hypergranulosis and acanthosis. Epidermal DNA synthesis was increased 3-fold compared with normal diet mice. Prostaglandin E (PGE) and prostaglandin F (PGF) levels, measured by radioimmunoassay, were much reduced in the EFA deficient mice skin. 10% Linoleic acid applied topically for 2 weeks corrected the gross and histological skin abnormalities and reduced epidermal DNA synthesis to normal values. The levels of PGE and PGF were only partially corrected. Linoleic acid applied to normal diet mice increased skin levels of PGE and PGF compared with the control vehicle treated normal diet mice. These results provide further evidence for the importance of essential fatty acids in the control of epidermal proliferation and differentiation. The importance of PGE and PGF in controlling epidermal DNA synthesis in EFA deficiency is less clear.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

641371

Citation

Lowe, N J., and P R. DeQuoy. "Linoleic Acid Effects On Epidermal DNA Synthesis and Cutaneous Prostaglandin Levels in Essential Fatty Acid Deficiency." The Journal of Investigative Dermatology, vol. 70, no. 4, 1978, pp. 200-3.
Lowe NJ, DeQuoy PR. Linoleic acid effects on epidermal DNA synthesis and cutaneous prostaglandin levels in essential fatty acid deficiency. J Invest Dermatol. 1978;70(4):200-3.
Lowe, N. J., & DeQuoy, P. R. (1978). Linoleic acid effects on epidermal DNA synthesis and cutaneous prostaglandin levels in essential fatty acid deficiency. The Journal of Investigative Dermatology, 70(4), 200-3.
Lowe NJ, DeQuoy PR. Linoleic Acid Effects On Epidermal DNA Synthesis and Cutaneous Prostaglandin Levels in Essential Fatty Acid Deficiency. J Invest Dermatol. 1978;70(4):200-3. PubMed PMID: 641371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linoleic acid effects on epidermal DNA synthesis and cutaneous prostaglandin levels in essential fatty acid deficiency. AU - Lowe,N J, AU - DeQuoy,P R, PY - 1978/4/1/pubmed PY - 1978/4/1/medline PY - 1978/4/1/entrez SP - 200 EP - 3 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 70 IS - 4 N2 - An essential fatty acid (EFA) deficient state has been induced in hairless mice. The epidermal changes included hyperkeratosis, hypergranulosis and acanthosis. Epidermal DNA synthesis was increased 3-fold compared with normal diet mice. Prostaglandin E (PGE) and prostaglandin F (PGF) levels, measured by radioimmunoassay, were much reduced in the EFA deficient mice skin. 10% Linoleic acid applied topically for 2 weeks corrected the gross and histological skin abnormalities and reduced epidermal DNA synthesis to normal values. The levels of PGE and PGF were only partially corrected. Linoleic acid applied to normal diet mice increased skin levels of PGE and PGF compared with the control vehicle treated normal diet mice. These results provide further evidence for the importance of essential fatty acids in the control of epidermal proliferation and differentiation. The importance of PGE and PGF in controlling epidermal DNA synthesis in EFA deficiency is less clear. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/641371/Linoleic_acid_effects_on_epidermal_DNA_synthesis_and_cutaneous_prostaglandin_levels_in_essential_fatty_acid_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)45235-2 DB - PRIME DP - Unbound Medicine ER -