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Primary structure of the variable region of a human lambda VI light chain: Bence Jones protein SUT.
J Immunol. 1983 Nov; 131(5):2490-3.JI

Abstract

To ascertain if lambda VI light chains have unique structural features that account for the preferential association of these proteins with primary or multiple myeloma-related amyloidosis (amyloidosis AL) we have determined the complete amino acid sequence of the variable (V) region of the lambda VI Bence Jones protein SUT. This protein, obtained from a patient with amyloidosis AL, represents a complete light chain consisting of 216 residues and it has structural and serologic properties characteristic for lambda VI light chains. The sequence of the joining segment (J) (positions 100 to 111) of protein SUT is identical to that of the J lambda I segment of the mouse IG lambda light chain gene. V region SUT is closely homologous in sequence to that of another lambda VI amyloid fibrillar protein, AR, differing by 21 residues. The V regions of proteins SUT and AR contain a two-residue insertion at positions 68 and 69 that has also been found in two other lambda VI human light chains but not in the lambda-chains of other V region subgroups.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6415173

Citation

Frangione, B, et al. "Primary Structure of the Variable Region of a Human Lambda VI Light Chain: Bence Jones Protein SUT." Journal of Immunology (Baltimore, Md. : 1950), vol. 131, no. 5, 1983, pp. 2490-3.
Frangione B, Moloshok T, Solomon A. Primary structure of the variable region of a human lambda VI light chain: Bence Jones protein SUT. J Immunol. 1983;131(5):2490-3.
Frangione, B., Moloshok, T., & Solomon, A. (1983). Primary structure of the variable region of a human lambda VI light chain: Bence Jones protein SUT. Journal of Immunology (Baltimore, Md. : 1950), 131(5), 2490-3.
Frangione B, Moloshok T, Solomon A. Primary Structure of the Variable Region of a Human Lambda VI Light Chain: Bence Jones Protein SUT. J Immunol. 1983;131(5):2490-3. PubMed PMID: 6415173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary structure of the variable region of a human lambda VI light chain: Bence Jones protein SUT. AU - Frangione,B, AU - Moloshok,T, AU - Solomon,A, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 2490 EP - 3 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 131 IS - 5 N2 - To ascertain if lambda VI light chains have unique structural features that account for the preferential association of these proteins with primary or multiple myeloma-related amyloidosis (amyloidosis AL) we have determined the complete amino acid sequence of the variable (V) region of the lambda VI Bence Jones protein SUT. This protein, obtained from a patient with amyloidosis AL, represents a complete light chain consisting of 216 residues and it has structural and serologic properties characteristic for lambda VI light chains. The sequence of the joining segment (J) (positions 100 to 111) of protein SUT is identical to that of the J lambda I segment of the mouse IG lambda light chain gene. V region SUT is closely homologous in sequence to that of another lambda VI amyloid fibrillar protein, AR, differing by 21 residues. The V regions of proteins SUT and AR contain a two-residue insertion at positions 68 and 69 that has also been found in two other lambda VI human light chains but not in the lambda-chains of other V region subgroups. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6415173/Primary_structure_of_the_variable_region_of_a_human_lambda_VI_light_chain:_Bence_Jones_protein_SUT_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=6415173 DB - PRIME DP - Unbound Medicine ER -