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The ultrastructure of urate crystals in gout.
J Rheumatol. 1978 Spring; 5(1):7-18.JR

Abstract

Using correlative scanning and transmission electron microscopic techniques, we studied the ultrastructure of natural and synthetic monosodium urate crystals. The internal architecture of both natural and synthetic urates consists of an interconnecting electron lucent network. This network is different in crystals from tophi, suggesting crystal formation about an electron lucent nidal matrix. Urate crystals from articular cartilage surfaces have smooth faces supporting the hypothesis that acute goat is a two phase process involving first the precipitation of urate crystals in the synovial fluid and second the adherence to the crystals of proteins and cells with the consequent inflammatory response.

Authors

Pritzker KP
No affiliation info available
Zahn CE
No affiliation info available
Nyburg SC
No affiliation info available
Luk SC
No affiliation info available
Houpt JB
No affiliation info available

MeSH

CrystallizationGoutHumansMicroscopy, ElectronMicroscopy, Electron, ScanningSynovial FluidUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

641916

Citation

Pritzker, K P., et al. "The Ultrastructure of Urate Crystals in Gout." The Journal of Rheumatology, vol. 5, no. 1, 1978, pp. 7-18.
Pritzker KP, Zahn CE, Nyburg SC, et al. The ultrastructure of urate crystals in gout. J Rheumatol. 1978;5(1):7-18.
Pritzker, K. P., Zahn, C. E., Nyburg, S. C., Luk, S. C., & Houpt, J. B. (1978). The ultrastructure of urate crystals in gout. The Journal of Rheumatology, 5(1), 7-18.
Pritzker KP, et al. The Ultrastructure of Urate Crystals in Gout. J Rheumatol. 1978;5(1):7-18. PubMed PMID: 641916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ultrastructure of urate crystals in gout. AU - Pritzker,K P, AU - Zahn,C E, AU - Nyburg,S C, AU - Luk,S C, AU - Houpt,J B, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 7 EP - 18 JF - The Journal of rheumatology JO - J Rheumatol VL - 5 IS - 1 N2 - Using correlative scanning and transmission electron microscopic techniques, we studied the ultrastructure of natural and synthetic monosodium urate crystals. The internal architecture of both natural and synthetic urates consists of an interconnecting electron lucent network. This network is different in crystals from tophi, suggesting crystal formation about an electron lucent nidal matrix. Urate crystals from articular cartilage surfaces have smooth faces supporting the hypothesis that acute goat is a two phase process involving first the precipitation of urate crystals in the synovial fluid and second the adherence to the crystals of proteins and cells with the consequent inflammatory response. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/641916/The_ultrastructure_of_urate_crystals_in_gout_ DB - PRIME DP - Unbound Medicine ER -