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Role of thromboxanes and prostaglandin endoperoxides in the pathogenesis of eicosanoid induced sudden death.
Thromb Res. 1983 Nov 01; 32(3):311-20.TR

Abstract

Arachidonic acid (1 mg/kg) or 9,11-azo PGH2 (35 micrograms/kg) injected intravenously into anesthetized rabbits results in sudden death characterized by a marked loss of circulating platelets, a dramatic rise in circulating thromboxane B2 concentrations and a precipitous drop in blood pressure. Death ensues in 3 to 5 minutes from pulmonary thrombosis and pulmonary artery constriction. Administration of dazoxiben (2 mg/kg) prior to arachidonic acid, prevents all of these changes. However, dazoxiben failed to prevent any of these effects after injection of azo-PGH2, a synthetic agonist of the endoperoxide and thromboxane receptor. These results demonstrate the importance of endoperoxide-thromboxane accumulation in eicosanoid induced sudden death and suggests that there is no significant functional difference between the actions of these agents in the rabbit.

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Publisher Full Text

Authors

Lefer AM
No affiliation info available
Burke SE
No affiliation info available
Smith JB
No affiliation info available

MeSH

AnimalsArachidonic AcidArachidonic AcidsDeath, SuddenImidazolesMalePlatelet AggregationProstaglandin EndoperoxidesProstaglandins HPulmonary EmbolismRabbitsThromboxane A2ThromboxanesVasoconstriction

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6419378

Citation

Lefer, A M., et al. "Role of Thromboxanes and Prostaglandin Endoperoxides in the Pathogenesis of Eicosanoid Induced Sudden Death." Thrombosis Research, vol. 32, no. 3, 1983, pp. 311-20.
Lefer AM, Burke SE, Smith JB. Role of thromboxanes and prostaglandin endoperoxides in the pathogenesis of eicosanoid induced sudden death. Thromb Res. 1983;32(3):311-20.
Lefer, A. M., Burke, S. E., & Smith, J. B. (1983). Role of thromboxanes and prostaglandin endoperoxides in the pathogenesis of eicosanoid induced sudden death. Thrombosis Research, 32(3), 311-20.
Lefer AM, Burke SE, Smith JB. Role of Thromboxanes and Prostaglandin Endoperoxides in the Pathogenesis of Eicosanoid Induced Sudden Death. Thromb Res. 1983 Nov 1;32(3):311-20. PubMed PMID: 6419378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of thromboxanes and prostaglandin endoperoxides in the pathogenesis of eicosanoid induced sudden death. AU - Lefer,A M, AU - Burke,S E, AU - Smith,J B, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 311 EP - 20 JF - Thrombosis research JO - Thromb Res VL - 32 IS - 3 N2 - Arachidonic acid (1 mg/kg) or 9,11-azo PGH2 (35 micrograms/kg) injected intravenously into anesthetized rabbits results in sudden death characterized by a marked loss of circulating platelets, a dramatic rise in circulating thromboxane B2 concentrations and a precipitous drop in blood pressure. Death ensues in 3 to 5 minutes from pulmonary thrombosis and pulmonary artery constriction. Administration of dazoxiben (2 mg/kg) prior to arachidonic acid, prevents all of these changes. However, dazoxiben failed to prevent any of these effects after injection of azo-PGH2, a synthetic agonist of the endoperoxide and thromboxane receptor. These results demonstrate the importance of endoperoxide-thromboxane accumulation in eicosanoid induced sudden death and suggests that there is no significant functional difference between the actions of these agents in the rabbit. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/6419378/Role_of_thromboxanes_and_prostaglandin_endoperoxides_in_the_pathogenesis_of_eicosanoid_induced_sudden_death_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0049-3848(83)90166-4 DB - PRIME DP - Unbound Medicine ER -