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Thyrotropin (TSH)-induced hyperthyroidism: response of TSH to dopamine and its agonists.
J Clin Endocrinol Metab. 1984 Feb; 58(2):255-61.JC

Abstract

A 12-yr-old girl with the syndrome of hyperthyroidism due to inappropriate TSH secretion, who had no evidence of pituitary tumor, was studied in detail. She had undergone two thyroidectomies for recurrent goiter and hyperthyroidism before referral. Basal serum TSH levels were extremely high (maximum 173 microU/ml), and the TSH response to TRH was exaggerated (peak, 675 microU/ml). The serum alpha-subunit of TSH was normal. PRL and other anterior pituitary hormone studies were normal. Dopamine infusion at 2 and 4 micrograms/kg X min partially suppressed TSH and PRL secretion and their responses to TRH. Bromocriptine had a paradoxical effect, resulting in an increase in TRH-stimulated TSH levels. Pergolide, a newer dopamine agonist, significantly decreased per basal serum TSH and blunted the TSH response to TRH; however, despite progressive dose increases, her TSH level was not reduced to normal.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6420433

Citation

Sriwatanakul, K, et al. "Thyrotropin (TSH)-induced Hyperthyroidism: Response of TSH to Dopamine and Its Agonists." The Journal of Clinical Endocrinology and Metabolism, vol. 58, no. 2, 1984, pp. 255-61.
Sriwatanakul K, McCormick K, Woolf P. Thyrotropin (TSH)-induced hyperthyroidism: response of TSH to dopamine and its agonists. J Clin Endocrinol Metab. 1984;58(2):255-61.
Sriwatanakul, K., McCormick, K., & Woolf, P. (1984). Thyrotropin (TSH)-induced hyperthyroidism: response of TSH to dopamine and its agonists. The Journal of Clinical Endocrinology and Metabolism, 58(2), 255-61.
Sriwatanakul K, McCormick K, Woolf P. Thyrotropin (TSH)-induced Hyperthyroidism: Response of TSH to Dopamine and Its Agonists. J Clin Endocrinol Metab. 1984;58(2):255-61. PubMed PMID: 6420433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyrotropin (TSH)-induced hyperthyroidism: response of TSH to dopamine and its agonists. AU - Sriwatanakul,K, AU - McCormick,K, AU - Woolf,P, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 255 EP - 61 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 58 IS - 2 N2 - A 12-yr-old girl with the syndrome of hyperthyroidism due to inappropriate TSH secretion, who had no evidence of pituitary tumor, was studied in detail. She had undergone two thyroidectomies for recurrent goiter and hyperthyroidism before referral. Basal serum TSH levels were extremely high (maximum 173 microU/ml), and the TSH response to TRH was exaggerated (peak, 675 microU/ml). The serum alpha-subunit of TSH was normal. PRL and other anterior pituitary hormone studies were normal. Dopamine infusion at 2 and 4 micrograms/kg X min partially suppressed TSH and PRL secretion and their responses to TRH. Bromocriptine had a paradoxical effect, resulting in an increase in TRH-stimulated TSH levels. Pergolide, a newer dopamine agonist, significantly decreased per basal serum TSH and blunted the TSH response to TRH; however, despite progressive dose increases, her TSH level was not reduced to normal. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6420433/Thyrotropin__TSH__induced_hyperthyroidism:_response_of_TSH_to_dopamine_and_its_agonists_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-58-2-255 DB - PRIME DP - Unbound Medicine ER -