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On the significance of giant somatosensory evoked potentials in cortical myoclonus.
J Neurol Neurosurg Psychiatry. 1984 Jan; 47(1):33-42.JN

Abstract

Four patients with cortical myoclonus were studied. All had reflex muscle jerking and grossly enlarged somatosensory evoked responses (SEPs) following electrical stimulation of the digital nerves. In addition, three of the patients had spontaneous or action-induced myoclonus. Back-averaging the EEG from these spontaneous muscle jerks showed a large positive wave over the contralateral somatomotor cortex which preceded the jerk by about 20 ms. Administration of lisuride (0.1 mg iv) reduced the severity of the reflex and spontaneous myoclonus, but had no effect on, or increased the size of the SEP. Two of the patients also received 1 mg clonazepam iv. As with lisuride, the severity of myoclonic jerking was reduced although the size of the SEP was increased. It is concluded that the usual association between giant SEPs and reflex muscle jerking can be abolished by acute administration of lisuride and clonazepam in patients with cortical myoclonus.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6420519

Citation

Rothwell, J C., et al. "On the Significance of Giant Somatosensory Evoked Potentials in Cortical Myoclonus." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 47, no. 1, 1984, pp. 33-42.
Rothwell JC, Obeso JA, Marsden CD. On the significance of giant somatosensory evoked potentials in cortical myoclonus. J Neurol Neurosurg Psychiatry. 1984;47(1):33-42.
Rothwell, J. C., Obeso, J. A., & Marsden, C. D. (1984). On the significance of giant somatosensory evoked potentials in cortical myoclonus. Journal of Neurology, Neurosurgery, and Psychiatry, 47(1), 33-42.
Rothwell JC, Obeso JA, Marsden CD. On the Significance of Giant Somatosensory Evoked Potentials in Cortical Myoclonus. J Neurol Neurosurg Psychiatry. 1984;47(1):33-42. PubMed PMID: 6420519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the significance of giant somatosensory evoked potentials in cortical myoclonus. AU - Rothwell,J C, AU - Obeso,J A, AU - Marsden,C D, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 33 EP - 42 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 47 IS - 1 N2 - Four patients with cortical myoclonus were studied. All had reflex muscle jerking and grossly enlarged somatosensory evoked responses (SEPs) following electrical stimulation of the digital nerves. In addition, three of the patients had spontaneous or action-induced myoclonus. Back-averaging the EEG from these spontaneous muscle jerks showed a large positive wave over the contralateral somatomotor cortex which preceded the jerk by about 20 ms. Administration of lisuride (0.1 mg iv) reduced the severity of the reflex and spontaneous myoclonus, but had no effect on, or increased the size of the SEP. Two of the patients also received 1 mg clonazepam iv. As with lisuride, the severity of myoclonic jerking was reduced although the size of the SEP was increased. It is concluded that the usual association between giant SEPs and reflex muscle jerking can be abolished by acute administration of lisuride and clonazepam in patients with cortical myoclonus. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/6420519/On_the_significance_of_giant_somatosensory_evoked_potentials_in_cortical_myoclonus_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=6420519 DB - PRIME DP - Unbound Medicine ER -