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Tardive dyskinesia associated with metoclopramide.
Br Med J (Clin Res Ed) 1984; 288(6416):545-7BM

Abstract

Eleven cases of tardive dyskinesia associated with metoclopramide have been reported to the Swedish Adverse Drug Reactions Advisory Committee from 1977 to 1981, 10 of which developed during the past three years. All patients were women, with a mean age of 76 years. Median duration of treatment before the onset of symptoms was 14 months. Calculated from total drug sales and prescription statistics the incidence of tardive dyskinesia during treatment with metoclopramide was estimated to be one in 2000-2800 treatment years. Extrapolation of data on long term treatment (more than six months) of patients aged 70 years or more, from a survey based on individual prescriptions yielded an incidence of more than one in a 1000 patients. Long term treatment with metoclopramide is accompanied by a substantial risk of developing tardive dyskinesia especially among elderly people.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6421373

Citation

Wiholm, B E., et al. "Tardive Dyskinesia Associated With Metoclopramide." British Medical Journal (Clinical Research Ed.), vol. 288, no. 6416, 1984, pp. 545-7.
Wiholm BE, Mortimer O, Boethius G, et al. Tardive dyskinesia associated with metoclopramide. Br Med J (Clin Res Ed). 1984;288(6416):545-7.
Wiholm, B. E., Mortimer, O., Boethius, G., & Häggström, J. E. (1984). Tardive dyskinesia associated with metoclopramide. British Medical Journal (Clinical Research Ed.), 288(6416), pp. 545-7.
Wiholm BE, et al. Tardive Dyskinesia Associated With Metoclopramide. Br Med J (Clin Res Ed). 1984 Feb 18;288(6416):545-7. PubMed PMID: 6421373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tardive dyskinesia associated with metoclopramide. AU - Wiholm,B E, AU - Mortimer,O, AU - Boethius,G, AU - Häggström,J E, PY - 1984/2/18/pubmed PY - 1984/2/18/medline PY - 1984/2/18/entrez SP - 545 EP - 7 JF - British medical journal (Clinical research ed.) JO - Br Med J (Clin Res Ed) VL - 288 IS - 6416 N2 - Eleven cases of tardive dyskinesia associated with metoclopramide have been reported to the Swedish Adverse Drug Reactions Advisory Committee from 1977 to 1981, 10 of which developed during the past three years. All patients were women, with a mean age of 76 years. Median duration of treatment before the onset of symptoms was 14 months. Calculated from total drug sales and prescription statistics the incidence of tardive dyskinesia during treatment with metoclopramide was estimated to be one in 2000-2800 treatment years. Extrapolation of data on long term treatment (more than six months) of patients aged 70 years or more, from a survey based on individual prescriptions yielded an incidence of more than one in a 1000 patients. Long term treatment with metoclopramide is accompanied by a substantial risk of developing tardive dyskinesia especially among elderly people. SN - 0267-0623 UR - https://www.unboundmedicine.com/medline/citation/6421373/Tardive_dyskinesia_associated_with_metoclopramide_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6421373/ DB - PRIME DP - Unbound Medicine ER -