Tags

Type your tag names separated by a space and hit enter

Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate.
Arch Gen Psychiatry. 1984 Apr; 41(4):391-7.AG

Abstract

Serum cortisol levels were significantly increased following administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, to patients with affective disorders. A three- to five-week period of treatment with lithium carbonate or monoamine oxidase (MAO) inhibitor augmented the mean 5-HTP-induced increase in serum cortisol concentration in manic or depressed patients, respectively: tricyclic antidepressant (TCA) and second-generation antidepressant treatment diminished the mean serum cortisol response in patients with major depression. These results are consistent with the hypothesis that lithium carbonate may enhance serotonin (5-HT) receptor sensitivity, whereas TCA and second-generation antidepressants diminish 5-HT receptor sensitivity. The enhancement of the cortisol response to 5-HTP by MAO inhibitors may be due to decreased metabolism of 5-HT. It is important to assess the effect of thymoleptic drug treatment on various responses to biogenic amine precursors or agonists in patients rather than laboratory animals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6422900

Citation

Meltzer, H Y., et al. "Effect of 5-hydroxytryptophan On Serum Cortisol Levels in Major Affective Disorders. III. Effect of Antidepressants and Lithium Carbonate." Archives of General Psychiatry, vol. 41, no. 4, 1984, pp. 391-7.
Meltzer HY, Lowy M, Robertson A, et al. Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. Arch Gen Psychiatry. 1984;41(4):391-7.
Meltzer, H. Y., Lowy, M., Robertson, A., Goodnick, P., & Perline, R. (1984). Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. Archives of General Psychiatry, 41(4), 391-7.
Meltzer HY, et al. Effect of 5-hydroxytryptophan On Serum Cortisol Levels in Major Affective Disorders. III. Effect of Antidepressants and Lithium Carbonate. Arch Gen Psychiatry. 1984;41(4):391-7. PubMed PMID: 6422900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. AU - Meltzer,H Y, AU - Lowy,M, AU - Robertson,A, AU - Goodnick,P, AU - Perline,R, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 391 EP - 7 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 41 IS - 4 N2 - Serum cortisol levels were significantly increased following administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, to patients with affective disorders. A three- to five-week period of treatment with lithium carbonate or monoamine oxidase (MAO) inhibitor augmented the mean 5-HTP-induced increase in serum cortisol concentration in manic or depressed patients, respectively: tricyclic antidepressant (TCA) and second-generation antidepressant treatment diminished the mean serum cortisol response in patients with major depression. These results are consistent with the hypothesis that lithium carbonate may enhance serotonin (5-HT) receptor sensitivity, whereas TCA and second-generation antidepressants diminish 5-HT receptor sensitivity. The enhancement of the cortisol response to 5-HTP by MAO inhibitors may be due to decreased metabolism of 5-HT. It is important to assess the effect of thymoleptic drug treatment on various responses to biogenic amine precursors or agonists in patients rather than laboratory animals. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/6422900/Effect_of_5_hydroxytryptophan_on_serum_cortisol_levels_in_major_affective_disorders__III__Effect_of_antidepressants_and_lithium_carbonate_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/vol/41/pg/391 DB - PRIME DP - Unbound Medicine ER -