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The deoxyuridine suppression test.
Crit Rev Clin Lab Sci. 1984; 20(3):205-41.CR

Abstract

The deoxyuridine suppression (dU) test, first described in 1964, has gained an important place both in the diagnosis of megaloblastic anemias and in the study of vitamin B12 folate interrelationships in the pathogenesis of megaloblastic anemia. The test measures the integrity of the de novo synthetic pathway of DNA synthesis, in which vitamin B12 and folate play an essential role. The exact mechanism of the test is still largely unknown. However, it is probably the most sensitive and specific functional test for the establishment of vitamin B12 and/or folate deficiency. As such, it is an important diagnostic tool in the investigation of patients suspected of suffering from deficiency of either or both of these vitamins. The test may also have applications towards the study of other factors required for the de novo synthesis of DNA.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

6426860

Citation

Metz, J. "The Deoxyuridine Suppression Test." Critical Reviews in Clinical Laboratory Sciences, vol. 20, no. 3, 1984, pp. 205-41.
Metz J. The deoxyuridine suppression test. Crit Rev Clin Lab Sci. 1984;20(3):205-41.
Metz, J. (1984). The deoxyuridine suppression test. Critical Reviews in Clinical Laboratory Sciences, 20(3), 205-41.
Metz J. The Deoxyuridine Suppression Test. Crit Rev Clin Lab Sci. 1984;20(3):205-41. PubMed PMID: 6426860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The deoxyuridine suppression test. A1 - Metz,J, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 205 EP - 41 JF - Critical reviews in clinical laboratory sciences JO - Crit Rev Clin Lab Sci VL - 20 IS - 3 N2 - The deoxyuridine suppression (dU) test, first described in 1964, has gained an important place both in the diagnosis of megaloblastic anemias and in the study of vitamin B12 folate interrelationships in the pathogenesis of megaloblastic anemia. The test measures the integrity of the de novo synthetic pathway of DNA synthesis, in which vitamin B12 and folate play an essential role. The exact mechanism of the test is still largely unknown. However, it is probably the most sensitive and specific functional test for the establishment of vitamin B12 and/or folate deficiency. As such, it is an important diagnostic tool in the investigation of patients suspected of suffering from deficiency of either or both of these vitamins. The test may also have applications towards the study of other factors required for the de novo synthesis of DNA. SN - 1040-8363 UR - https://www.unboundmedicine.com/medline/citation/6426860/The_deoxyuridine_suppression_test_ L2 - https://www.tandfonline.com/doi/full/10.3109/10408368409165775 DB - PRIME DP - Unbound Medicine ER -