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Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out.
Curr Med Res Opin. 1984; 9(1):52-5.CM

Abstract

A comparative experimental study was carried out in guinea-pigs to assess the effect of pentoxifylline on inner ear perfusion. Five animals were given a single dose of 30 mg pentoxifylline per 10-minute intravenous infusion and the cochlear blood flow measured by means of the hydrogen-clearance technique before and after administration of the drug. A control group of 11 animals received the solvent only. Compared to controls, a significant increase in inner ear blood flow was observed in the pentoxifylline-treated animals. These data may explain positive clinical findings with pentoxifylline in otological disorders associated with impaired cochlear perfusion.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6426863

Citation

Maass, B, and D Ludwig. "Effect of Pentoxifylline ('Trental') On Cochlear Blood Flow as Measured By Hydrogen Wash-out." Current Medical Research and Opinion, vol. 9, no. 1, 1984, pp. 52-5.
Maass B, Ludwig D. Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out. Curr Med Res Opin. 1984;9(1):52-5.
Maass, B., & Ludwig, D. (1984). Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out. Current Medical Research and Opinion, 9(1), 52-5.
Maass B, Ludwig D. Effect of Pentoxifylline ('Trental') On Cochlear Blood Flow as Measured By Hydrogen Wash-out. Curr Med Res Opin. 1984;9(1):52-5. PubMed PMID: 6426863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out. AU - Maass,B, AU - Ludwig,D, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 52 EP - 5 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 9 IS - 1 N2 - A comparative experimental study was carried out in guinea-pigs to assess the effect of pentoxifylline on inner ear perfusion. Five animals were given a single dose of 30 mg pentoxifylline per 10-minute intravenous infusion and the cochlear blood flow measured by means of the hydrogen-clearance technique before and after administration of the drug. A control group of 11 animals received the solvent only. Compared to controls, a significant increase in inner ear blood flow was observed in the pentoxifylline-treated animals. These data may explain positive clinical findings with pentoxifylline in otological disorders associated with impaired cochlear perfusion. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/6426863/Effect_of_pentoxifylline__'Trental'__on_cochlear_blood_flow_as_measured_by_hydrogen_wash_out_ L2 - http://www.tandfonline.com/doi/full/10.1185/03007998409109559 DB - PRIME DP - Unbound Medicine ER -