Tags

Type your tag names separated by a space and hit enter

Gonadotropin and prolactin pulsations in hyperprolactinemic women before and during bromocriptine therapy.
J Clin Endocrinol Metab. 1984 Jun; 58(6):1141-7.JC

Abstract

Pulsatile gonadotropin secretion and its relationship to PRL and estradiol (E2) secretion were investigated in 20 hyperprolactinemic amenorrheic women by obtaining serial blood samples for 6- to 24-h periods. Thirteen patients were restudied in the early follicular phase of the menstrual cycle (days 3-5) after ovulatory periods were established during bromocriptine therapy. In the hyperprolactinemic women, the number of LH peaks ranged from 0-12/24 h, and LH peak amplitude ranged from 0-1.7 mIU/ml. Serum E2 correlated with mean LH concentrations (P less than 0.001) and LH pulse frequency (P less than 0.05), but not with LH pulse amplitude. FSH pulsations were identified in 3 of the 20 women. There was no correlation between mean FSH concentrations and either serum E2 or PRL. There was a significant correlation between LH and FSH concentrations (P less than 0.001). During bromocriptine therapy, with comparable E2 concentrations, 5 of the 6 patients studied with blood sampling every 20 min for 24 h had a significant decrease (P less than 0.01) in the number of LH peaks per 24 h, with no change in LH peak amplitude. Mean FSH concentrations were unchanged in bromocriptine-treated patients; however, there was a significant (P less than 0.02) decrease in FSH levels during sleep. Serum PRL was normal in all bromocriptine-treated patients, but normal PRL secretory patterns were not reestablished, and there was no correlation between LH pulsations and serum PRL concentrations. We conclude that 1) hyperprolactinemic women have a heterogeneous pattern of pulsatile gonadotropin secretion; 2) serum E2 correlates with LH pulse frequency but not pulse amplitude; 3) LH pulsations and PRL pulsations are asynchronous in hyperprolactinemic women before and during bromocriptine therapy; and 4) normal PRL secretory patterns are not required for ovulatory function in hyperprolactinemic women treated with bromocriptine.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6427260

Citation

Klibanski, A, et al. "Gonadotropin and Prolactin Pulsations in Hyperprolactinemic Women Before and During Bromocriptine Therapy." The Journal of Clinical Endocrinology and Metabolism, vol. 58, no. 6, 1984, pp. 1141-7.
Klibanski A, Beitins IZ, Merriam GR, et al. Gonadotropin and prolactin pulsations in hyperprolactinemic women before and during bromocriptine therapy. J Clin Endocrinol Metab. 1984;58(6):1141-7.
Klibanski, A., Beitins, I. Z., Merriam, G. R., McArthur, J. W., Zervas, N. T., & Ridgway, E. C. (1984). Gonadotropin and prolactin pulsations in hyperprolactinemic women before and during bromocriptine therapy. The Journal of Clinical Endocrinology and Metabolism, 58(6), 1141-7.
Klibanski A, et al. Gonadotropin and Prolactin Pulsations in Hyperprolactinemic Women Before and During Bromocriptine Therapy. J Clin Endocrinol Metab. 1984;58(6):1141-7. PubMed PMID: 6427260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gonadotropin and prolactin pulsations in hyperprolactinemic women before and during bromocriptine therapy. AU - Klibanski,A, AU - Beitins,I Z, AU - Merriam,G R, AU - McArthur,J W, AU - Zervas,N T, AU - Ridgway,E C, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 1141 EP - 7 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 58 IS - 6 N2 - Pulsatile gonadotropin secretion and its relationship to PRL and estradiol (E2) secretion were investigated in 20 hyperprolactinemic amenorrheic women by obtaining serial blood samples for 6- to 24-h periods. Thirteen patients were restudied in the early follicular phase of the menstrual cycle (days 3-5) after ovulatory periods were established during bromocriptine therapy. In the hyperprolactinemic women, the number of LH peaks ranged from 0-12/24 h, and LH peak amplitude ranged from 0-1.7 mIU/ml. Serum E2 correlated with mean LH concentrations (P less than 0.001) and LH pulse frequency (P less than 0.05), but not with LH pulse amplitude. FSH pulsations were identified in 3 of the 20 women. There was no correlation between mean FSH concentrations and either serum E2 or PRL. There was a significant correlation between LH and FSH concentrations (P less than 0.001). During bromocriptine therapy, with comparable E2 concentrations, 5 of the 6 patients studied with blood sampling every 20 min for 24 h had a significant decrease (P less than 0.01) in the number of LH peaks per 24 h, with no change in LH peak amplitude. Mean FSH concentrations were unchanged in bromocriptine-treated patients; however, there was a significant (P less than 0.02) decrease in FSH levels during sleep. Serum PRL was normal in all bromocriptine-treated patients, but normal PRL secretory patterns were not reestablished, and there was no correlation between LH pulsations and serum PRL concentrations. We conclude that 1) hyperprolactinemic women have a heterogeneous pattern of pulsatile gonadotropin secretion; 2) serum E2 correlates with LH pulse frequency but not pulse amplitude; 3) LH pulsations and PRL pulsations are asynchronous in hyperprolactinemic women before and during bromocriptine therapy; and 4) normal PRL secretory patterns are not required for ovulatory function in hyperprolactinemic women treated with bromocriptine. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6427260/Gonadotropin_and_prolactin_pulsations_in_hyperprolactinemic_women_before_and_during_bromocriptine_therapy_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-58-6-1141 DB - PRIME DP - Unbound Medicine ER -