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Responses to leukotriene C4 in the perfused rat lung.
J Pharmacol Exp Ther. 1984 Jun; 229(3):654-7.JP

Abstract

The isolated rat lung was used to study both the effect of leukotriene C4 on pulmonary perfusion pressure and the synthesis and release of cyclooxygenase products in the pulmonary circulation. A cell-free perfusate was passed only once through the pulmonary circulation or was recirculated. During single transit, leukotriene C4 produced dose-dependent increases in pulmonary perfusion pressure that were abolished by FPL-55712, a leukotriene receptor antagonist, but were not altered significantly by indomethacin. The duration of the pulmonary pressor response to leukotriene C4 was markedly prolonged during recirculation compared to single transit. Leukotriene C4 also induced dose-dependent increases in effluent levels of 6-keto-prostaglandin F1 alpha and thromboxane B2 that were attenuated by indomethacin or FPL-55712 pretreatment. We conclude that leukotriene C4 directly constricts the pulmonary vasculature independent of cyclooxygenase products, is not rapidly degraded by the pulmonary circulation and stimulates the release of cyclooxygenase products in the pulmonary circulation that can be attenuated by pretreatment with indomethacin or FPL-55712.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6427447

Citation

Iacopino, V J., et al. "Responses to Leukotriene C4 in the Perfused Rat Lung." The Journal of Pharmacology and Experimental Therapeutics, vol. 229, no. 3, 1984, pp. 654-7.
Iacopino VJ, Compton S, Fitzpatrick T, et al. Responses to leukotriene C4 in the perfused rat lung. J Pharmacol Exp Ther. 1984;229(3):654-7.
Iacopino, V. J., Compton, S., Fitzpatrick, T., Ramwell, P., Rose, J., & Kot, P. (1984). Responses to leukotriene C4 in the perfused rat lung. The Journal of Pharmacology and Experimental Therapeutics, 229(3), 654-7.
Iacopino VJ, et al. Responses to Leukotriene C4 in the Perfused Rat Lung. J Pharmacol Exp Ther. 1984;229(3):654-7. PubMed PMID: 6427447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Responses to leukotriene C4 in the perfused rat lung. AU - Iacopino,V J, AU - Compton,S, AU - Fitzpatrick,T, AU - Ramwell,P, AU - Rose,J, AU - Kot,P, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 654 EP - 7 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 229 IS - 3 N2 - The isolated rat lung was used to study both the effect of leukotriene C4 on pulmonary perfusion pressure and the synthesis and release of cyclooxygenase products in the pulmonary circulation. A cell-free perfusate was passed only once through the pulmonary circulation or was recirculated. During single transit, leukotriene C4 produced dose-dependent increases in pulmonary perfusion pressure that were abolished by FPL-55712, a leukotriene receptor antagonist, but were not altered significantly by indomethacin. The duration of the pulmonary pressor response to leukotriene C4 was markedly prolonged during recirculation compared to single transit. Leukotriene C4 also induced dose-dependent increases in effluent levels of 6-keto-prostaglandin F1 alpha and thromboxane B2 that were attenuated by indomethacin or FPL-55712 pretreatment. We conclude that leukotriene C4 directly constricts the pulmonary vasculature independent of cyclooxygenase products, is not rapidly degraded by the pulmonary circulation and stimulates the release of cyclooxygenase products in the pulmonary circulation that can be attenuated by pretreatment with indomethacin or FPL-55712. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/6427447/Responses_to_leukotriene_C4_in_the_perfused_rat_lung_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=6427447 DB - PRIME DP - Unbound Medicine ER -