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Liver involvement in nonamyloid light chain deposits disease.
Lab Invest. 1984 Jun; 50(6):683-9.LI

Abstract

Liver examination performed in seven patients who had renal failure related to light chain deposits demonstrated in all cases the presence of liver light chain deposits. In all of our patients clinical renal involvement antedated the liver disease. The portal areas and the Disse spaces contained a granular material which strongly reacted with antilight chain antiserum (kappa or gamma). In one patient in whom lesions were severe, the sinusoid edge was ruptured and a pelliosis -like lesion was observed. In the five patients who were hemodialyzed for more than several months at the time of discovery of liver deposits, increased amounts of collagen were present in the Disse spaces, and one patient had extensive liver fibrosis by light microscopy. Clinical liver involvement was defined by moderate hepatomegaly in five patients, with ascites in two. A slight increase in phosphatase alkaline activity was frequently observed and bromsulphalein retention was present in two. In one patient liver tests remained entirely normal despite the presence of diffuse kappa light chain deposits.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6427520

Citation

Droz, D, et al. "Liver Involvement in Nonamyloid Light Chain Deposits Disease." Laboratory Investigation; a Journal of Technical Methods and Pathology, vol. 50, no. 6, 1984, pp. 683-9.
Droz D, Noel LH, Carnot F, et al. Liver involvement in nonamyloid light chain deposits disease. Lab Invest. 1984;50(6):683-9.
Droz, D., Noel, L. H., Carnot, F., Degos, F., Ganeval, D., & Grunfeld, J. P. (1984). Liver involvement in nonamyloid light chain deposits disease. Laboratory Investigation; a Journal of Technical Methods and Pathology, 50(6), 683-9.
Droz D, et al. Liver Involvement in Nonamyloid Light Chain Deposits Disease. Lab Invest. 1984;50(6):683-9. PubMed PMID: 6427520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver involvement in nonamyloid light chain deposits disease. AU - Droz,D, AU - Noel,L H, AU - Carnot,F, AU - Degos,F, AU - Ganeval,D, AU - Grunfeld,J P, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 683 EP - 9 JF - Laboratory investigation; a journal of technical methods and pathology JO - Lab Invest VL - 50 IS - 6 N2 - Liver examination performed in seven patients who had renal failure related to light chain deposits demonstrated in all cases the presence of liver light chain deposits. In all of our patients clinical renal involvement antedated the liver disease. The portal areas and the Disse spaces contained a granular material which strongly reacted with antilight chain antiserum (kappa or gamma). In one patient in whom lesions were severe, the sinusoid edge was ruptured and a pelliosis -like lesion was observed. In the five patients who were hemodialyzed for more than several months at the time of discovery of liver deposits, increased amounts of collagen were present in the Disse spaces, and one patient had extensive liver fibrosis by light microscopy. Clinical liver involvement was defined by moderate hepatomegaly in five patients, with ascites in two. A slight increase in phosphatase alkaline activity was frequently observed and bromsulphalein retention was present in two. In one patient liver tests remained entirely normal despite the presence of diffuse kappa light chain deposits. SN - 0023-6837 UR - https://www.unboundmedicine.com/medline/citation/6427520/Liver_involvement_in_nonamyloid_light_chain_deposits_disease_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -