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Effects of the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH on the pituitary-gonadal axis of prepubertal rhesus monkeys.
Biol Reprod. 1984 Jun; 30(5):1130-4.BR

Abstract

To elucidate whether the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH (LHRHa) decreases plasma testosterone levels in male primates solely by inhibiting gonadotropin secretion or, in addition, by inhibiting testicular testosterone biosynthesis, we have investigated the effects of this drug on 6 infant male rhesus monkeys. Three animals received LHRHa (12 micrograms . kg . day s.c., experimental group), and 3 animals received saline injections (control group) during the first 2 mo of life. Mean plasma testosterone was significantly lower in the experimental group compared to the control group (54 +/- 7 ng/dl vs. 501 +/- 52 ng/dl, P less than 0.001). The experimental group also had significantly lower mean follicle-stimulating hormone (FSH; 5.1 +/- 0.2 microgram/ml vs. 9.6 +/- 0.7 microgram/ml, P less than 0.001), and bioactive luteinizing hormone (LH; 2.0 +/- 0.08 microgram/ml vs. 3.5 +/- 0.2 microgram/ml, P less than 0.001). To study whether LHRHa influences testicular function directly, all animals were treated with human chorionic gonadotropin (hCG; 100 mIU . kg . day i.m.) for 28 days beginning at 8 mo of age. During Days 15 through 28 we administered LHRHa 12 micrograms . kg . day s.c. to the experimental animals and saline injections to the control group. Plasma testosterone increased to 5827 +/- 557 ng/dl in the experimental group and 4440 +/- 897 ng/dl in the control group after 14 days of hCG treatment. Plasma testosterone concentrations decreased in both groups of animals from Days 15 to 28 fo the study. All steroid intermediates were similar in both groups of animals on Days 14 and 28.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6428479

Citation

Cassorla, F, et al. "Effects of the Luteinizing Hormone-releasing Hormone (LHRH) Analog D-Trp6-Pro9-NEt-LHRH On the Pituitary-gonadal Axis of Prepubertal Rhesus Monkeys." Biology of Reproduction, vol. 30, no. 5, 1984, pp. 1130-4.
Cassorla F, Renquist D, Barnard D, et al. Effects of the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH on the pituitary-gonadal axis of prepubertal rhesus monkeys. Biol Reprod. 1984;30(5):1130-4.
Cassorla, F., Renquist, D., Barnard, D., Munabi, A. K., Cutler, G. B., & Loriaux, D. L. (1984). Effects of the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH on the pituitary-gonadal axis of prepubertal rhesus monkeys. Biology of Reproduction, 30(5), 1130-4.
Cassorla F, et al. Effects of the Luteinizing Hormone-releasing Hormone (LHRH) Analog D-Trp6-Pro9-NEt-LHRH On the Pituitary-gonadal Axis of Prepubertal Rhesus Monkeys. Biol Reprod. 1984;30(5):1130-4. PubMed PMID: 6428479.
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TY - JOUR T1 - Effects of the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH on the pituitary-gonadal axis of prepubertal rhesus monkeys. AU - Cassorla,F, AU - Renquist,D, AU - Barnard,D, AU - Munabi,A K, AU - Cutler,G B,Jr AU - Loriaux,D L, PY - 1984/6/1/pubmed PY - 2001/3/28/medline PY - 1984/6/1/entrez SP - 1130 EP - 4 JF - Biology of reproduction JO - Biol Reprod VL - 30 IS - 5 N2 - To elucidate whether the luteinizing hormone-releasing hormone (LHRH) analog D-Trp6-Pro9-NEt-LHRH (LHRHa) decreases plasma testosterone levels in male primates solely by inhibiting gonadotropin secretion or, in addition, by inhibiting testicular testosterone biosynthesis, we have investigated the effects of this drug on 6 infant male rhesus monkeys. Three animals received LHRHa (12 micrograms . kg . day s.c., experimental group), and 3 animals received saline injections (control group) during the first 2 mo of life. Mean plasma testosterone was significantly lower in the experimental group compared to the control group (54 +/- 7 ng/dl vs. 501 +/- 52 ng/dl, P less than 0.001). The experimental group also had significantly lower mean follicle-stimulating hormone (FSH; 5.1 +/- 0.2 microgram/ml vs. 9.6 +/- 0.7 microgram/ml, P less than 0.001), and bioactive luteinizing hormone (LH; 2.0 +/- 0.08 microgram/ml vs. 3.5 +/- 0.2 microgram/ml, P less than 0.001). To study whether LHRHa influences testicular function directly, all animals were treated with human chorionic gonadotropin (hCG; 100 mIU . kg . day i.m.) for 28 days beginning at 8 mo of age. During Days 15 through 28 we administered LHRHa 12 micrograms . kg . day s.c. to the experimental animals and saline injections to the control group. Plasma testosterone increased to 5827 +/- 557 ng/dl in the experimental group and 4440 +/- 897 ng/dl in the control group after 14 days of hCG treatment. Plasma testosterone concentrations decreased in both groups of animals from Days 15 to 28 fo the study. All steroid intermediates were similar in both groups of animals on Days 14 and 28.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0006-3363 UR - https://www.unboundmedicine.com/medline/citation/6428479/Effects_of_the_luteinizing_hormone_releasing_hormone__LHRH__analog_D_Trp6_Pro9_NEt_LHRH_on_the_pituitary_gonadal_axis_of_prepubertal_rhesus_monkeys_ L2 - https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod30.5.1130 DB - PRIME DP - Unbound Medicine ER -