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Ovarian function is effectively inhibited by a low-dose triphasic oral contraceptive containing ethinylestradiol and levonorgestrel.
Contraception. 1984 Apr; 29(4):305-18.C

Abstract

For various metabolic and clinical reasons, it has been strongly advocated to reduce the dose of both the estrogen and progestogen components of oral contraceptives (OCs). In this study, we compared after 6 months of treatment, the action on various hormonal parameters of a standard-dose combined OC containing ethinylestradiol (EE) 0.050 mg and levonorgestrel (LNg) 0.250 mg and a low-dose triphasic combination containing a 59% reduced amount of the same steroids. Hormonal measurements in the last 3 days of OC intake indicated that basal levels of FSH and LH were less inhibited by the low-dose preparation, while PRL levels were unchanged. However, gonadal function was effectively inhibited by both high and low dose OCs, as demonstrated by equally low levels of E2, E1, P and 17-P. Consequently, no residual gonadal function could be anticipated from the observed low steroid concentrations. These results corroborated other studies (reviewed in this paper) in which serial hormonal measurements also revealed a complete lack of follicular maturation during low-dose triphasic OC treatment. Moreover, inhibition of circulating levels of A, DHEA, DHEAS, free T and DHT was similarly obtained with both preparations. Collectively, these data indicate that ovarian function is as effectively inhibited by a low-dose triphasic preparation as by a higher, standard-dose OC containing the same steroids.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6430638

Citation

Gaspard, U J., et al. "Ovarian Function Is Effectively Inhibited By a Low-dose Triphasic Oral Contraceptive Containing Ethinylestradiol and Levonorgestrel." Contraception, vol. 29, no. 4, 1984, pp. 305-18.
Gaspard UJ, Dubois M, Gillain D, et al. Ovarian function is effectively inhibited by a low-dose triphasic oral contraceptive containing ethinylestradiol and levonorgestrel. Contraception. 1984;29(4):305-18.
Gaspard, U. J., Dubois, M., Gillain, D., Franchimont, P., & Duvivier, J. (1984). Ovarian function is effectively inhibited by a low-dose triphasic oral contraceptive containing ethinylestradiol and levonorgestrel. Contraception, 29(4), 305-18.
Gaspard UJ, et al. Ovarian Function Is Effectively Inhibited By a Low-dose Triphasic Oral Contraceptive Containing Ethinylestradiol and Levonorgestrel. Contraception. 1984;29(4):305-18. PubMed PMID: 6430638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovarian function is effectively inhibited by a low-dose triphasic oral contraceptive containing ethinylestradiol and levonorgestrel. AU - Gaspard,U J, AU - Dubois,M, AU - Gillain,D, AU - Franchimont,P, AU - Duvivier,J, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez KW - Androgens KW - Biology KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Corpus Luteum Hormones KW - Dehydroepiandrosterone KW - Diseases KW - Endocrine System KW - Estradiol KW - Estrogens KW - Estrone KW - Ethinyl Estradiol KW - Family Planning KW - Follicle Stimulating Hormone KW - Genital Effects, Female KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones--analysis KW - Levonorgestrel KW - Luteinizing Hormone KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Oral Contraceptives, Phasic KW - Ovarian Effects KW - Ovary KW - Physiology KW - Progesterone KW - Prolactin KW - Reproductive Control Agents KW - Urogenital Effects KW - Urogenital System SP - 305 EP - 18 JF - Contraception JO - Contraception VL - 29 IS - 4 N2 - For various metabolic and clinical reasons, it has been strongly advocated to reduce the dose of both the estrogen and progestogen components of oral contraceptives (OCs). In this study, we compared after 6 months of treatment, the action on various hormonal parameters of a standard-dose combined OC containing ethinylestradiol (EE) 0.050 mg and levonorgestrel (LNg) 0.250 mg and a low-dose triphasic combination containing a 59% reduced amount of the same steroids. Hormonal measurements in the last 3 days of OC intake indicated that basal levels of FSH and LH were less inhibited by the low-dose preparation, while PRL levels were unchanged. However, gonadal function was effectively inhibited by both high and low dose OCs, as demonstrated by equally low levels of E2, E1, P and 17-P. Consequently, no residual gonadal function could be anticipated from the observed low steroid concentrations. These results corroborated other studies (reviewed in this paper) in which serial hormonal measurements also revealed a complete lack of follicular maturation during low-dose triphasic OC treatment. Moreover, inhibition of circulating levels of A, DHEA, DHEAS, free T and DHT was similarly obtained with both preparations. Collectively, these data indicate that ovarian function is as effectively inhibited by a low-dose triphasic preparation as by a higher, standard-dose OC containing the same steroids. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/6430638/Ovarian_function_is_effectively_inhibited_by_a_low_dose_triphasic_oral_contraceptive_containing_ethinylestradiol_and_levonorgestrel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(84)90064-7 DB - PRIME DP - Unbound Medicine ER -