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Paradoxical response of thyrotropin to L-dopa and presence of dopaminergic receptors in a thyrotropin-secreting pituitary adenoma.
J Clin Endocrinol Metab. 1984 Sep; 59(3):542-6.JC

Abstract

We studied the dopaminergic control of TSH secretion in a patient with hyperthyroidism due to a TSH-secreting pituitary adenoma. A 34-yr-old previously thyroidectomized woman had mild clinical hyperthyroidism and a diffuse goiter without exophthalmos. She complained of headaches and had bitemporal hemianopsia. Serum T4 and T3 by RIA were elevated, and TSH was 112 microU/ml (normal range, 1.1-7.2). The alpha-subunit to TSH molar ratio was 1.7 (normal, less than 1), as reported in other patients with tumoral TSH hypersecretion. After TRH, a marked increase in TSH occurred. There was no evidence of pituitary deficiency. Skull x-rays and computerized axial tomography revealed an intrasellar tumor with suprasellar extension. Selective transsphenoidal adenomectomy was performed, and a pituitary tumor was removed. The tumor was almost entirely composed of cells reactive with antihuman beta TSH serum by indirect immunofluorescence. A unique feature of this patient was the marked increase in TSH levels after L-dopa administration. To our knowledge, this paradoxical response has never been reported previously in such patients. Using [3H]domperidone as ligand, dopaminergic receptors were demonstrated in the membranes of the adenomatous thyrotroph cells. The reason for the paradoxical response of TSH to dopaminergic agents is not known.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6430950

Citation

Chanson, P, et al. "Paradoxical Response of Thyrotropin to L-dopa and Presence of Dopaminergic Receptors in a Thyrotropin-secreting Pituitary Adenoma." The Journal of Clinical Endocrinology and Metabolism, vol. 59, no. 3, 1984, pp. 542-6.
Chanson P, Orgiazzi J, Derome PJ, et al. Paradoxical response of thyrotropin to L-dopa and presence of dopaminergic receptors in a thyrotropin-secreting pituitary adenoma. J Clin Endocrinol Metab. 1984;59(3):542-6.
Chanson, P., Orgiazzi, J., Derome, P. J., Bression, D., Jedynak, C. P., Trouillas, J., Legentil, P., Racadot, J., & Peillon, F. (1984). Paradoxical response of thyrotropin to L-dopa and presence of dopaminergic receptors in a thyrotropin-secreting pituitary adenoma. The Journal of Clinical Endocrinology and Metabolism, 59(3), 542-6.
Chanson P, et al. Paradoxical Response of Thyrotropin to L-dopa and Presence of Dopaminergic Receptors in a Thyrotropin-secreting Pituitary Adenoma. J Clin Endocrinol Metab. 1984;59(3):542-6. PubMed PMID: 6430950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paradoxical response of thyrotropin to L-dopa and presence of dopaminergic receptors in a thyrotropin-secreting pituitary adenoma. AU - Chanson,P, AU - Orgiazzi,J, AU - Derome,P J, AU - Bression,D, AU - Jedynak,C P, AU - Trouillas,J, AU - Legentil,P, AU - Racadot,J, AU - Peillon,F, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 542 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 59 IS - 3 N2 - We studied the dopaminergic control of TSH secretion in a patient with hyperthyroidism due to a TSH-secreting pituitary adenoma. A 34-yr-old previously thyroidectomized woman had mild clinical hyperthyroidism and a diffuse goiter without exophthalmos. She complained of headaches and had bitemporal hemianopsia. Serum T4 and T3 by RIA were elevated, and TSH was 112 microU/ml (normal range, 1.1-7.2). The alpha-subunit to TSH molar ratio was 1.7 (normal, less than 1), as reported in other patients with tumoral TSH hypersecretion. After TRH, a marked increase in TSH occurred. There was no evidence of pituitary deficiency. Skull x-rays and computerized axial tomography revealed an intrasellar tumor with suprasellar extension. Selective transsphenoidal adenomectomy was performed, and a pituitary tumor was removed. The tumor was almost entirely composed of cells reactive with antihuman beta TSH serum by indirect immunofluorescence. A unique feature of this patient was the marked increase in TSH levels after L-dopa administration. To our knowledge, this paradoxical response has never been reported previously in such patients. Using [3H]domperidone as ligand, dopaminergic receptors were demonstrated in the membranes of the adenomatous thyrotroph cells. The reason for the paradoxical response of TSH to dopaminergic agents is not known. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6430950/Paradoxical_response_of_thyrotropin_to_L_dopa_and_presence_of_dopaminergic_receptors_in_a_thyrotropin_secreting_pituitary_adenoma_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-59-3-542 DB - PRIME DP - Unbound Medicine ER -