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HLA phenotype and insulin antibody production.
Clin Exp Immunol. 1984 Aug; 57(2):443-8.CE

Abstract

HLA phenotypes have been determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6432385

Citation

Reeves, W G., et al. "HLA Phenotype and Insulin Antibody Production." Clinical and Experimental Immunology, vol. 57, no. 2, 1984, pp. 443-8.
Reeves WG, Gelsthorpe K, Van der Minne P, et al. HLA phenotype and insulin antibody production. Clin Exp Immunol. 1984;57(2):443-8.
Reeves, W. G., Gelsthorpe, K., Van der Minne, P., Torensma, R., & Tattersall, R. B. (1984). HLA phenotype and insulin antibody production. Clinical and Experimental Immunology, 57(2), 443-8.
Reeves WG, et al. HLA Phenotype and Insulin Antibody Production. Clin Exp Immunol. 1984;57(2):443-8. PubMed PMID: 6432385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA phenotype and insulin antibody production. AU - Reeves,W G, AU - Gelsthorpe,K, AU - Van der Minne,P, AU - Torensma,R, AU - Tattersall,R B, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 443 EP - 8 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 57 IS - 2 N2 - HLA phenotypes have been determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/6432385/HLA_phenotype_and_insulin_antibody_production_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6432385/ DB - PRIME DP - Unbound Medicine ER -