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Black-white differences in plasma levels of apolipoproteins: the Evans County Heart Study.
Am Heart J 1984; 108(3 Pt 2):807-14AH

Abstract

Evans County black males had lower ischemic heart disease (IHD) prevalence, incidence, and mortality than white males. High-density lipoprotein (HDL) cholesterol was lower in IHD cases than in subjects without IHD. HDL cholesterol and apolipoprotein A-I (Apo A-I) were higher and low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and Apo C-II were lower in black than white males. Of the black-white male HDL cholesterol difference, 22% was statistically explained by Apo A-I. Controlling for Apo C-II reduced the black-white differences in total cholesterol 87%, LDL cholesterol 44%, VLDL cholesterol 83%, and total triglyceride 83%. There were negative associations between Apo A-I and age, Quetelet index, and cigarettes smoked; the association between Apo A-I and alcohol was positive. Only body mass index and race were strong correlates of Apo C-II. The ratios of Apo A-I to Apo A-II and of HDL cholesterol to Apo A-II were higher in black than white males with adjustment for age, body mass, and cigarette and alcohol consumption. Thus black-white differences in total lipids, lipoprotein lipids, and lipoprotein apoproteins were observed, indicating a relatively antiatherogenic profile in black males only partially explained by known correlates.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6433686

Citation

Heiss, G, et al. "Black-white Differences in Plasma Levels of Apolipoproteins: the Evans County Heart Study." American Heart Journal, vol. 108, no. 3 Pt 2, 1984, pp. 807-14.
Heiss G, Schonfeld G, Johnson JL, et al. Black-white differences in plasma levels of apolipoproteins: the Evans County Heart Study. Am Heart J. 1984;108(3 Pt 2):807-14.
Heiss, G., Schonfeld, G., Johnson, J. L., Heyden, S., Hames, C. G., & Tyroler, H. A. (1984). Black-white differences in plasma levels of apolipoproteins: the Evans County Heart Study. American Heart Journal, 108(3 Pt 2), pp. 807-14.
Heiss G, et al. Black-white Differences in Plasma Levels of Apolipoproteins: the Evans County Heart Study. Am Heart J. 1984;108(3 Pt 2):807-14. PubMed PMID: 6433686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Black-white differences in plasma levels of apolipoproteins: the Evans County Heart Study. AU - Heiss,G, AU - Schonfeld,G, AU - Johnson,J L, AU - Heyden,S, AU - Hames,C G, AU - Tyroler,H A, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 807 EP - 14 JF - American heart journal JO - Am. Heart J. VL - 108 IS - 3 Pt 2 N2 - Evans County black males had lower ischemic heart disease (IHD) prevalence, incidence, and mortality than white males. High-density lipoprotein (HDL) cholesterol was lower in IHD cases than in subjects without IHD. HDL cholesterol and apolipoprotein A-I (Apo A-I) were higher and low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and Apo C-II were lower in black than white males. Of the black-white male HDL cholesterol difference, 22% was statistically explained by Apo A-I. Controlling for Apo C-II reduced the black-white differences in total cholesterol 87%, LDL cholesterol 44%, VLDL cholesterol 83%, and total triglyceride 83%. There were negative associations between Apo A-I and age, Quetelet index, and cigarettes smoked; the association between Apo A-I and alcohol was positive. Only body mass index and race were strong correlates of Apo C-II. The ratios of Apo A-I to Apo A-II and of HDL cholesterol to Apo A-II were higher in black than white males with adjustment for age, body mass, and cigarette and alcohol consumption. Thus black-white differences in total lipids, lipoprotein lipids, and lipoprotein apoproteins were observed, indicating a relatively antiatherogenic profile in black males only partially explained by known correlates. SN - 0002-8703 UR - https://www.unboundmedicine.com/medline/citation/6433686/Black_white_differences_in_plasma_levels_of_apolipoproteins:_the_Evans_County_Heart_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-8703(84)90676-8 DB - PRIME DP - Unbound Medicine ER -