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Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism.
Arch Intern Med. 1984 Sep; 144(9):1752-4.AI

Abstract

We gave graded doses of levothyroxine sodium to 11 elderly hypothyroid subjects (mean age, 66.1 years). The daily levothyroxine sodium dose was initially 75 micrograms or less, and was increased by 25 micrograms every six weeks. Serum total thyroxine, total triiodothyronine, and basal thyrotropin levels were measured at the start of the study and at the end of each six-week dose period. A protirelin (thyrotropin-releasing hormone) test was performed when the thyrotropin level returned to normal. Mean daily levothyroxine sodium doses that normalized serum thyrotropin levels and protirelin test were 110 +/- 8 micrograms and 113 +/- 9 micrograms, respectively. Serial basal thyrotropin determinations during stepwise increments in levothyroxine dose indicated physiologic hormone replacement. As determined in our elderly patients, levothyroxine replacement dose was a third less than that formerly recommended.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6433829

Citation

Davis, F B., et al. "Estimation of a Physiologic Replacement Dose of Levothyroxine in Elderly Patients With Hypothyroidism." Archives of Internal Medicine, vol. 144, no. 9, 1984, pp. 1752-4.
Davis FB, LaMantia RS, Spaulding SW, et al. Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism. Arch Intern Med. 1984;144(9):1752-4.
Davis, F. B., LaMantia, R. S., Spaulding, S. W., Wehmann, R. E., & Davis, P. J. (1984). Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism. Archives of Internal Medicine, 144(9), 1752-4.
Davis FB, et al. Estimation of a Physiologic Replacement Dose of Levothyroxine in Elderly Patients With Hypothyroidism. Arch Intern Med. 1984;144(9):1752-4. PubMed PMID: 6433829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism. AU - Davis,F B, AU - LaMantia,R S, AU - Spaulding,S W, AU - Wehmann,R E, AU - Davis,P J, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 1752 EP - 4 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 144 IS - 9 N2 - We gave graded doses of levothyroxine sodium to 11 elderly hypothyroid subjects (mean age, 66.1 years). The daily levothyroxine sodium dose was initially 75 micrograms or less, and was increased by 25 micrograms every six weeks. Serum total thyroxine, total triiodothyronine, and basal thyrotropin levels were measured at the start of the study and at the end of each six-week dose period. A protirelin (thyrotropin-releasing hormone) test was performed when the thyrotropin level returned to normal. Mean daily levothyroxine sodium doses that normalized serum thyrotropin levels and protirelin test were 110 +/- 8 micrograms and 113 +/- 9 micrograms, respectively. Serial basal thyrotropin determinations during stepwise increments in levothyroxine dose indicated physiologic hormone replacement. As determined in our elderly patients, levothyroxine replacement dose was a third less than that formerly recommended. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/6433829/Estimation_of_a_physiologic_replacement_dose_of_levothyroxine_in_elderly_patients_with_hypothyroidism_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/144/pg/1752 DB - PRIME DP - Unbound Medicine ER -