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Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung.
Br J Pharmacol. 1984 Aug; 82(4):871-6.BJ

Abstract

The nonsteroidal anti-inflammatory drugs (NSAID) indomethacin and mefenamic acid, at concentrations ranging from 3 microM to 18 microM, enhanced antigen-induced slow reacting substance of anaphylaxis (SRS-A) release from sensitized fragmented guinea-pig lung. In contrast, these agents had no effect on SRS-A release from nonsensitized guinea-pig lung induced by several concentrations of the calcium ionophore, A23187. Neither increasing preincubation time with the NSAID nor the use of sensitized tissue resulted in an enhancement of A23187-induced SRS-A release by indomethacin. NSAID did not alter histamine release by either stimulus. These results suggest that antigen and A23187 induce SRS-A release from different sources or by different mechanisms in guinea-pig lung.

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Authors

Krell RD
No affiliation info available
Kusner EJ
No affiliation info available

MeSH

6-Ketoprostaglandin F1 alphaAnimalsAnti-Inflammatory AgentsAntigensCalcimycinCyclooxygenase InhibitorsEpoprostenolExtracellular SpaceGuinea PigsHistamineIn Vitro TechniquesIonophoresLungMaleMefenamic AcidSRS-AThromboxane B2

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6434013

Citation

Krell, R D., and E J. Kusner. "Differential Effect of Cyclo-oxygenase Inhibition On Antigen- and Ionophore-induced Release of Slow Reacting Substance From Fragmented Guinea-pig Lung." British Journal of Pharmacology, vol. 82, no. 4, 1984, pp. 871-6.
Krell RD, Kusner EJ. Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung. Br J Pharmacol. 1984;82(4):871-6.
Krell, R. D., & Kusner, E. J. (1984). Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung. British Journal of Pharmacology, 82(4), 871-6.
Krell RD, Kusner EJ. Differential Effect of Cyclo-oxygenase Inhibition On Antigen- and Ionophore-induced Release of Slow Reacting Substance From Fragmented Guinea-pig Lung. Br J Pharmacol. 1984;82(4):871-6. PubMed PMID: 6434013.
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TY - JOUR T1 - Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung. AU - Krell,R D, AU - Kusner,E J, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 871 EP - 6 JF - British journal of pharmacology JO - Br J Pharmacol VL - 82 IS - 4 N2 - The nonsteroidal anti-inflammatory drugs (NSAID) indomethacin and mefenamic acid, at concentrations ranging from 3 microM to 18 microM, enhanced antigen-induced slow reacting substance of anaphylaxis (SRS-A) release from sensitized fragmented guinea-pig lung. In contrast, these agents had no effect on SRS-A release from nonsensitized guinea-pig lung induced by several concentrations of the calcium ionophore, A23187. Neither increasing preincubation time with the NSAID nor the use of sensitized tissue resulted in an enhancement of A23187-induced SRS-A release by indomethacin. NSAID did not alter histamine release by either stimulus. These results suggest that antigen and A23187 induce SRS-A release from different sources or by different mechanisms in guinea-pig lung. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/6434013/Differential_effect_of_cyclo_oxygenase_inhibition_on_antigen__and_ionophore_induced_release_of_slow_reacting_substance_from_fragmented_guinea_pig_lung_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1984&volume=82&issue=4&spage=871 DB - PRIME DP - Unbound Medicine ER -