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[Diabetic autonomic neuropathy of the heart and its treatment with thioctic acid].
Dtsch Z Verdau Stoffwechselkr 1984; 44(4):173-80DZ

Abstract

The therapeutic effect of thioctic acid was studied in two groups of patients with peripheral diabetic neuropathy (N = 34 and 27, resp.), who had no evidence of cardiovascular or respiratory insufficiency. The immediate heart-rate response to standing up was measured in the first group of diabetics and in nondiabetic controls (N = 33). Each subject lay quietly for three minutes, then stood up (within five seconds) and remained motionless for one minute. A continuous ECG was recorded from one minute before to one minute after standing. For the Valsalva manoeuvre, the diabetics of the second group were asked to blow a column of mercury up to a height of 40 mm Hg for 10 seconds. The patients were treated with thioctic acid in daily oral doses of 3 X 150 mg for 21 days. No changes of heart rate were found in 80% (standing up) and 59% (Valsalva) resp., in the diabetics with peripheral neuropathy. However, non-diabetic controls of the same age group had likewise no changes of heart rate response in 19 and 5%, respectively. Treatment with thioctic acid did not alter the heart rate response to standing up or Valsalva manoeuvre of the diabetics with peripheral neuropathy.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6434286

Citation

Studt, J, and L J. Heuer. "[Diabetic Autonomic Neuropathy of the Heart and Its Treatment With Thioctic Acid]." Deutsche Zeitschrift Fur Verdauungs- Und Stoffwechselkrankheiten, vol. 44, no. 4, 1984, pp. 173-80.
Studt J, Heuer LJ. [Diabetic autonomic neuropathy of the heart and its treatment with thioctic acid]. Dtsch Z Verdau Stoffwechselkr. 1984;44(4):173-80.
Studt, J., & Heuer, L. J. (1984). [Diabetic autonomic neuropathy of the heart and its treatment with thioctic acid]. Deutsche Zeitschrift Fur Verdauungs- Und Stoffwechselkrankheiten, 44(4), pp. 173-80.
Studt J, Heuer LJ. [Diabetic Autonomic Neuropathy of the Heart and Its Treatment With Thioctic Acid]. Dtsch Z Verdau Stoffwechselkr. 1984;44(4):173-80. PubMed PMID: 6434286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diabetic autonomic neuropathy of the heart and its treatment with thioctic acid]. AU - Studt,J, AU - Heuer,L J, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 173 EP - 80 JF - Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten JO - Dtsch Z Verdau Stoffwechselkr VL - 44 IS - 4 N2 - The therapeutic effect of thioctic acid was studied in two groups of patients with peripheral diabetic neuropathy (N = 34 and 27, resp.), who had no evidence of cardiovascular or respiratory insufficiency. The immediate heart-rate response to standing up was measured in the first group of diabetics and in nondiabetic controls (N = 33). Each subject lay quietly for three minutes, then stood up (within five seconds) and remained motionless for one minute. A continuous ECG was recorded from one minute before to one minute after standing. For the Valsalva manoeuvre, the diabetics of the second group were asked to blow a column of mercury up to a height of 40 mm Hg for 10 seconds. The patients were treated with thioctic acid in daily oral doses of 3 X 150 mg for 21 days. No changes of heart rate were found in 80% (standing up) and 59% (Valsalva) resp., in the diabetics with peripheral neuropathy. However, non-diabetic controls of the same age group had likewise no changes of heart rate response in 19 and 5%, respectively. Treatment with thioctic acid did not alter the heart rate response to standing up or Valsalva manoeuvre of the diabetics with peripheral neuropathy. SN - 0012-1053 UR - https://www.unboundmedicine.com/medline/citation/6434286/[Diabetic_autonomic_neuropathy_of_the_heart_and_its_treatment_with_thioctic_acid]_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -