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Gonadotropin response to gonadotropin releasing hormone in acute schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry. 1984; 8(3):411-7.PN

Abstract

To evaluate hypothalamic-pituitary-gonadal axis in acute schizophrenia, plasma FSH and LH concentrations were estimated both in basal conditions and after stimulation with gonadotropin releasing hormone (GnRH, 200 micrograms i.v.) in 14 young male patients with acute schizophrenia and in a age-matched group of 14 healthy male controls. Basal plasma PRL and testosterone levels were also measured. The mean basal levels of LH and FSH were slightly lower in schizophrenics, while the mean testosterone and prolactin levels were similar in the two groups. The FSH response to GnRH was significantly reduced in patients with acute schizophrenia, while the response of LH was similar in schizophrenics and in the controls. The possible significance of these findings is discussed in the contest of the complex neuroendocrine regulation of gonadotropin secretion and the overactivity of dopaminergic systems in acute schizophrenia.

Authors

Cantalamessa L
No affiliation info available
Catania A
No affiliation info available
Silva A
No affiliation info available
Orsatti A
No affiliation info available
Baldini M
No affiliation info available
Mosca G
No affiliation info available
Zanussi C
No affiliation info available
Cazzullo CL
No affiliation info available

MeSH

Acute DiseaseAdolescentAdultFollicle Stimulating HormoneHumansHypothalamo-Hypophyseal SystemLuteinizing HormoneMalePituitary Hormone-Releasing HormonesProlactinSchizophreniaTestisTestosterone

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6435179

Citation

Cantalamessa, L, et al. "Gonadotropin Response to Gonadotropin Releasing Hormone in Acute Schizophrenia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 8, no. 3, 1984, pp. 411-7.
Cantalamessa L, Catania A, Silva A, et al. Gonadotropin response to gonadotropin releasing hormone in acute schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(3):411-7.
Cantalamessa, L., Catania, A., Silva, A., Orsatti, A., Baldini, M., Mosca, G., Zanussi, C., & Cazzullo, C. L. (1984). Gonadotropin response to gonadotropin releasing hormone in acute schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 8(3), 411-7.
Cantalamessa L, et al. Gonadotropin Response to Gonadotropin Releasing Hormone in Acute Schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(3):411-7. PubMed PMID: 6435179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gonadotropin response to gonadotropin releasing hormone in acute schizophrenia. AU - Cantalamessa,L, AU - Catania,A, AU - Silva,A, AU - Orsatti,A, AU - Baldini,M, AU - Mosca,G, AU - Zanussi,C, AU - Cazzullo,C L, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 411 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 8 IS - 3 N2 - To evaluate hypothalamic-pituitary-gonadal axis in acute schizophrenia, plasma FSH and LH concentrations were estimated both in basal conditions and after stimulation with gonadotropin releasing hormone (GnRH, 200 micrograms i.v.) in 14 young male patients with acute schizophrenia and in a age-matched group of 14 healthy male controls. Basal plasma PRL and testosterone levels were also measured. The mean basal levels of LH and FSH were slightly lower in schizophrenics, while the mean testosterone and prolactin levels were similar in the two groups. The FSH response to GnRH was significantly reduced in patients with acute schizophrenia, while the response of LH was similar in schizophrenics and in the controls. The possible significance of these findings is discussed in the contest of the complex neuroendocrine regulation of gonadotropin secretion and the overactivity of dopaminergic systems in acute schizophrenia. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/6435179/Gonadotropin_response_to_gonadotropin_releasing_hormone_in_acute_schizophrenia_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -