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The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study.
Acta Otolaryngol. 1984 Sep-Oct; 98(3-4):231-8.AO

Abstract

As part of preliminary studies for an investigation to assess the place of some drugs, including tocainide HCl, in the treatment of tinnitus, the present study was performed to establish the appropriate dose for tocainide. The effect of lidocaine HCl on tinnitus was studied in a double-blind controlled cross-over study in 22 patients. Lidocaine appeared to give significant relief. To select an optimal daily dose for the lidocaine analog tocainide HCl, this drug was administered orally to 19 patients with obstructive tinnitus in seven 4-day periods. This could be done in a single-blind controlled trial. A different dose was given in each period. Comparison of the effect on tinnitus and the associated side effects led to the choice of a daily dose of 900 mg. The effect of lidocaine HCl appeared to have no prognostic value for the effect of tocainide HCl on the tinnitus in the individual patient.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6437131

Citation

Hulshof, J H., and P Vermeij. "The Effect of Intra-venous Lidocaine and Several Different Doses Oral Tocainide HCl On Tinnitus. a Dose-finding Study." Acta Oto-laryngologica, vol. 98, no. 3-4, 1984, pp. 231-8.
Hulshof JH, Vermeij P. The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study. Acta Otolaryngol. 1984;98(3-4):231-8.
Hulshof, J. H., & Vermeij, P. (1984). The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study. Acta Oto-laryngologica, 98(3-4), 231-8.
Hulshof JH, Vermeij P. The Effect of Intra-venous Lidocaine and Several Different Doses Oral Tocainide HCl On Tinnitus. a Dose-finding Study. Acta Otolaryngol. 1984 Sep-Oct;98(3-4):231-8. PubMed PMID: 6437131.
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TY - JOUR T1 - The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study. AU - Hulshof,J H, AU - Vermeij,P, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 231 EP - 8 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 98 IS - 3-4 N2 - As part of preliminary studies for an investigation to assess the place of some drugs, including tocainide HCl, in the treatment of tinnitus, the present study was performed to establish the appropriate dose for tocainide. The effect of lidocaine HCl on tinnitus was studied in a double-blind controlled cross-over study in 22 patients. Lidocaine appeared to give significant relief. To select an optimal daily dose for the lidocaine analog tocainide HCl, this drug was administered orally to 19 patients with obstructive tinnitus in seven 4-day periods. This could be done in a single-blind controlled trial. A different dose was given in each period. Comparison of the effect on tinnitus and the associated side effects led to the choice of a daily dose of 900 mg. The effect of lidocaine HCl appeared to have no prognostic value for the effect of tocainide HCl on the tinnitus in the individual patient. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/6437131/The_effect_of_intra_venous_lidocaine_and_several_different_doses_oral_tocainide_HCl_on_tinnitus__A_dose_finding_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016488409107559 DB - PRIME DP - Unbound Medicine ER -